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Automated GMP-produ...
Automated GMP-production of α-[11 C]methyl-L-tryptophan using a tracer production system (TPS)
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- Nordeman, Patrik, Docent (author)
- Uppsala universitet,Preparativ läkemedelskemi
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- Yngve, Ulrika, 1972- (author)
- Uppsala universitet,Institutionen för läkemedelskemi,Science for Life Laboratory, SciLifeLab,Drug Discovery and Development Platform
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Wilking, Helena (author)
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Gustavsson, Sven Åke (author)
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- Eriksson, Jonas (author)
- Uppsala universitet,Preparativ läkemedelskemi
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- Antoni, Gunnar (author)
- Uppsala universitet,Preparativ läkemedelskemi
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(creator_code:org_t)
- 2018-06-26
- 2018
- English.
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In: Journal of labelled compounds & radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 61:14, s. 1106-1109
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The radiosynthesis and GMP validation of [11 C]AMT for human use are described. Three consecutive batches were produced giving 940-3790 MBq (4%-17% RCY, decay corrected, based on [11 C]CO2 ) of the tracer. The molar activity at the end of synthesis was 19 to 35 GBq/μmol, the radiochemical purity was ≥98%, and the enantiomeric purity was >99%. While the synthesis method was automated using a new generation of synthesis equipment, tracer production system developed in house, the method should be readily applicable to other synthesis platforms with minor modifications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Keyword
- [11C]AMT
- automation
- methyl iodide
- positron emission tomography
- tracer production system
Publication and Content Type
- ref (subject category)
- art (subject category)
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