The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch

Gao, TianleUppsala universitet,Institutionen för neurovetenskap,Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China (author)

Itch is a somatosensory modality that serves to alert an organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch, whereas chemical itch was unaffected. We examined the effect of activating the NPY/Y-1 receptor system on scratch behavior in mice. We found that intrathecal administration of the Y-1 agonist [Leu(31), Pro(34)]-NPY (LP-NPY) attenuated itch behavior induced by application of 0.07 g von Frey filament in the nape of the neck compared with saline treatment, indicating that activation of the spinal NPY/Y-1 system dampens mechanical itch. However, intrathecal administration of LP-NPY also attenuated chemically induced scratching provoked by intradermal application of histamine or the mast cell degranulator 48/80 (histaminergic itch), and the latter effect could be reversed by administration of the Y-1 antagonist BIBO3304. Intrathecal application of the native nonselective agonist NPY also attenuated histamine or 48/80-induced scratching. Our analyses emphasize the importance of including additional quantitative parameters to characterize the full spectrum of itch behavior and show that the NPY/Y-1 system dampens both mechanically and chemically induced scratching and hence is shared by the two submodalities of itch.

Ma, HaishaUppsala universitet,Genetisk utvecklingsbiologi(Swepub:uu)haima817 (author)
Xu, Bo,1980-Uppsala universitet,Institutionen för neurovetenskap(Swepub:uu)boaxu109 (author)
Bergman, JessicaUppsala universitet,Institutionen för neurovetenskap(Swepub:uu)jesbe762 (author)
Larhammar, Dan,1956-Uppsala universitet,Farmakologi(Swepub:uu)dla05000 (author)
Lagerström, Malin C.Uppsala universitet,Genetisk utvecklingsbiologi(Swepub:uu)malag504 (author)
Uppsala universitetInstitutionen för neurovetenskap (creator_code:org_t)

In:Journal of Investigative Dermatology: ELSEVIER SCIENCE INC138:11, s. 2405-24110022-202X1523-1747

By the author/editor: Gao, Tianle; Ma, Haisha; Xu, Bo, 1980-; Bergman, Jessica; Larhammar, Dan, ...; Lagerström, Mali ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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