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  • Corsonello, AndreaKarolinska Institutet,INRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy (author)

Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study : a multicenter cohort observational study

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-10-11
  • BMC,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-369107
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369107URI
  • https://doi.org/10.1186/s12882-018-1030-2DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139391109URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-28715URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months-follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.

Subject headings and genre

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  • Tap, LisanneErasmus Univ, Geriatr Med Sect, Dept Internal Med, Med Ctr Rotterdam, Rotterdam, Netherlands (author)
  • Roller-Wirnsberger, ReginaMed Univ Graz, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria (author)
  • Wirnsberger, GerhardMed Univ Graz, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria (author)
  • Zoccali, CarmineOsped Riuniti Reggio Calabria, CNR, IFC, Clin Epidemiol & Pathophysiol Hypertens & Renal D, Reggio Di Calabria, Italy (author)
  • Kostka, TomaszMed Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland (author)
  • Guligowska, AgnieszkaMed Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland (author)
  • Mattace-Raso, FrancescoErasmus Univ, Geriatr Med Sect, Dept Internal Med, Med Ctr Rotterdam, Rotterdam, Netherlands (author)
  • Gil, PedroHosp Clin San Carlos, Dept Geriatr Med, Madrid, Spain (author)
  • Guardado Fuentes, LaraHosp Clin San Carlos, Dept Geriatr Med, Madrid, Spain (author)
  • Meltzer, ItshakBen Gurion Univ Negev, Fac Hlth Sci, Recanati Sch Community Hlth Profess, Beer Sheva, Israel (author)
  • Yehoshua, IlanMaccabi Healthcare Serv Southern Reg, Tel Aviv, Israel (author)
  • Formiga-Perez, FrancescBellvitge Univ Hosp, Internal Med Dept, IDIBELL, Geriatr Unit, Barcelona, Spain;Bellvitge Univ Hosp, Nephrol Dept, IDIBELL, Barcelona, Spain (author)
  • Moreno-Gonzalez, RafaelBellvitge Univ Hosp, Internal Med Dept, IDIBELL, Geriatr Unit, Barcelona, Spain;Bellvitge Univ Hosp, Nephrol Dept, IDIBELL, Barcelona, Spain (author)
  • Weingart, ChristianFriedrich Alexander Univ Erlangen Nurnberg, Krankenhaus Barmherzige Bruder Regensburg, Dept Gen Internal Med & Geriatr, Erlangen, Germany;Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging, Erlangen, Germany (author)
  • Freiberger, EllenFriedrich Alexander Univ Erlangen Nurnberg, Krankenhaus Barmherzige Bruder Regensburg, Dept Gen Internal Med & Geriatr, Erlangen, Germany;Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging, Erlangen, Germany (author)
  • Ärnlöv, JohanHögskolan Dalarna,Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Stockholm, Sweden,Medicinsk vetenskap,Uppsala universitet; Karolinska institutet(Swepub:du)jan (author)
  • Carlsson, Axel CUppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Stockholm, Sweden(Swepub:uu)axeca883 (author)
  • Bustacchini, SilviaINRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy (author)
  • Lattanzio, FabriziaINRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy (author)
  • Karolinska InstitutetINRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy (creator_code:org_t)

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  • In:BMC Nephrology: BMC191471-2369

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