Molecular parallelism in fast-twitch muscle proteins in echolocating mammals

Lee, Jun-HoeUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi,Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany;Max Planck Inst Phys Komplexer Syst, Dresden, Germany;Ctr Syst Biol Dresden, Dresden, Germany (author)

Detecting associations between genomic changes and phenotypic differences is fundamental to understanding how phenotypes evolved. By systematically screening for parallel amino acid substitutions, we detected known as well as novel cases (Strc, Tecta, and Cabp2) of parallelism between echolocating bats and toothed whales in proteins that could contribute to high-frequency hearing adaptations. Our screen also showed that echolocating mammals exhibit an unusually high number of parallel substitutions in fast-twitch muscle fiber proteins. Both echolocating bats and toothed whales produce an extremely rapid call rate when homing in on their prey, which was shown in bats to be powered by specialized superfast muscles. We show that these genes with parallel substitutions (Casq1, Atp2a1, Myh2, and Myl1) are expressed in the superfast sound-producing muscle of bats. Furthermore, we found that the calcium storage protein calsequestrin 1 of the little brown bat and the bottlenose dolphin functionally converged in its ability to form calcium-sequestering polymers at lower calcium concentrations, which may contribute to rapid calcium transients required for superfast muscle physiology. The proteins that our genomic screen detected could be involved in the convergent evolution of vocalization in echolocating mammals by potentially contributing to both rapid Ca2+ transients and increased shortening velocities in superfast muscles.

Lewis, Kevin M.Washington State Univ, Dept Chem, Pullman, WA 99164 USA (author)
Moural, Timothy W.Washington State Univ, Dept Chem, Pullman, WA 99164 USA (author)
Kirilenko, BogdanMax Planck Inst Mol Cell Biol & Genet, Dresden, Germany;Max Planck Inst Phys Komplexer Syst, Dresden, Germany;Ctr Syst Biol Dresden, Dresden, Germany (author)
Borgonovo, BarbaraMax Planck Inst Mol Cell Biol & Genet, Dresden, Germany (author)
Prange, GisaGoethe Univ Frankfurt, Inst Cell Biol & Neurosci, Frankfurt, Germany (author)
Koessl, ManfredGoethe Univ Frankfurt, Inst Cell Biol & Neurosci, Frankfurt, Germany (author)
Huggenberger, StefanUniv Cologne, Dept Anat Neuroanat, Cologne, Germany (author)
Kang, ChulHeeWashington State Univ, Dept Chem, Pullman, WA 99164 USA (author)
Hiller, MichaelMax Planck Inst Mol Cell Biol & Genet, Dresden, Germany;Max Planck Inst Phys Komplexer Syst, Dresden, Germany;Ctr Syst Biol Dresden, Dresden, Germany (author)
Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

In:Science Advances: American Association for the Advancement of Science (AAAS)4:92375-2548

By the author/editor: Lee, Jun-Hoe; Lewis, Kevin M.; Moural, Timothy ...; Kirilenko, Bogda ...; Borgonovo, Barba ...; Prange, Gisa; show more...; Koessl, Manfred; Huggenberger, St ...; Kang, ChulHee; Hiller, Michael; show less...

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