Predictive Value of High-Sensitivity Troponin T for Systolic Dysfunction and Infarct Size (Six Months) After ST-Elevation Myocardial Infarction

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Predictive Value of High-Sensitivity Troponin T for Systolic Dysfunction and Infarct Size (Six Months) After ST-Elevation Myocardial Infarction

Mohammad, Moman A. (author): Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital

Koul, Sasha (author): Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital

Smith, J. Gustav (author): Lund University,Lunds universitet,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,Lund University Research Groups

Noc, Marco (author): Ctr Intens Internal Med, Ljubljana, Slovenia,University Medical Centre Ljubljana

Lang, Irene (author): Med Univ Vienna, Dept Cardiol, Vienna, Austria,Medical University of Vienna

Holzer, Michael (author): Med Univ Vienna, Dept Emergency Med, Vienna, Austria,Medical University of Vienna

Clemmensen, Peter (author): Univ Heart Ctr, Dept Gen & Intervent Cardiol, Hamburg, Germany;Univ Southern Denmark, Nykoebing F Hosp, Div Cardiol, Dept Med, Odense, Denmark,University of Southern Denmark,University Medical Center Hamburg-Eppendorf

Jensen, Ulf (author): Karolinska Institute

Engstrøm, Thomas (author): Univ Copenhagen, Rigshosp, Heart Ctr, Copenhagen, Denmark,University of Copenhagen

Arheden, Håkan (author): Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital

James, Stefan K, 1964- (author): Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital

Lindahl, Bertil, 1957- (author): Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital

Metzler, Bernhard (author): Dept Cardiol, Innsbruck, Austria,Medical University of Innsbruck

Erlinge, David (author): Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital

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EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2018
2018
English.
In: American Journal of Cardiology. - : EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC. - 0002-9149 .- 1879-1913. ; 122:5, s. 735-743

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Journal article (peer-reviewed)

Abstract Subject headings

The association of markers of myocardial injury and dysfunction with infarct size (IS) and ejection fraction (EF) are well documented. However, limited data are available on the newer high-sensitivity troponin assays and comparison with morphologic and functional assessment with cardiac magnetic resonance imaging. We aimed to examine the associations of high-sensitivity cardiac Troponin-T (hs-cTnT), creatine kinase MB iso-enzyme (CKMB), and N-terminal pro B-type Natriuretic Peptide (NT-proBNP) to IS and EF at 6 months. Blood samples from 119 ST-segment elevation myocardial infarction patients from the Rapid Endovascular Catheter Core Cooling Combined With Cold Saline solution as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction trial were collected at baseline, 6, 24, and 48 hours after admission. Cardiac magnetic resonance was performed at 4 +/- 2 days and 6 months. The association of biomarker levels to IS and EF was tested with Pearson's correlation coefficients and linear regression models with bootstrap resampling. The correlation coefficient of biomarker to IS was (CKMB: r = 0.71); (NT-proBNP: r = 0.55); (hs-cTnT: r = 0.80); and for EF (CKMB: r = 0.57); (NT-proBNP: r = 0.48); and (peak hs-cTnT: r = 0.68). IS and EF at 4 +/- 2 days had the strongest correlations with IS and EF at 6 months respectively (IS: r = 0.84) and (EF: r = 0.74). Receiver operating characteristic of peak hs-cTnT for predicting EF <= 40% at 6 months was 0.87 compared with 0.75 for early IS. Early EF was a negative predictor of late EF <40%, 1-area under curve = 0.93. In conclusion, high-sensitivity Troponin T is a rapid, cheap, generally available tool for accurate prediction of systolic dysfunction in patients 6 months after first-time ST-segment elevation myocardial infarction.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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By the author/editor: Mohammad, Moman ...; Koul, Sasha; Smith, J. Gustav; Noc, Marco; Lang, Irene; Holzer, Michael; show more...; Clemmensen, Pete ...; Jensen, Ulf; Engstrøm, Thomas; Arheden, Håkan; James, Stefan K, ...; Lindahl, Bertil, ...; Metzler, Bernhar ...; Erlinge, David; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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By the university: Uppsala University; Karolinska Institutet; Lund University

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