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- Koyi, HirshKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Gavle Cent Hosp, Dept Resp Med, S-80187 Gavle, Sweden;Karolinska Inst, Stockholm, Sweden (author)
Co-localisation of Glandular and Squamous Cell Markers in Non-small Cell Lung Cancer
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-05-30
- Anticancer Research USA Inc.2018
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-371061
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-371061URI
- https://doi.org/10.21873/anticanres.12600DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:139540981URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Aim: Accurate classification of lung carcinomas is crucial for selecting appropriate and adequate chemotherapy treatment. In this study, glandular (adenocarcinoma), and squamous cell differentiation were examined in non-small cell lung carcinoma (NSCLC) without obvious light-microscopic signs of squamous and glandular differentiation. Materials and Methods: All lung tumours diagnosed as NSCLC (n=61), without obvious squamous or glandular features, were obtained by bronchial biopsy or core biopsy supported by computed tomography. They were diagnosed during 1996-2009, at the Department of Pathology, Gavle Hospital, Sweden. The tumours were examined immunohistochemically with antibodies against CK5/6, p63 (squamous cell markers) and carcinoembryonic antigen (CEA) (adenocarcinoma cell marker). Double immunostaining (p63/CEA) was also performed on individual tumours. Results: The tumours originated from 36 males and 25 females, aged 54-83 years. Pure squamous cell differentiation (CK5/6 positive only) occurred in 34.4% (n=21) tumours and pure adenocarcinoma cell differentiation (CEA positive only) was present in 14.9% (n=9). Tumours with both squamous and adenocarcinoma features (CK5/6 and CEA positive) were most prevalent (47.5%, n=29). Two tumours (3.3%) were negative with both stains (and also synaptophysin negative). Double immunostaining (p63/CEA) revealed that squamous and adenocarcinoma markers were co-localised in cells in certain tumours. Conclusion: Co-localisation of squamous and adenocarcinoma markers in the same tumour cell suggests that additional analyses for novel biomarkers of specific lung cancer types may subsequently lead to a refined treatment choice for patients with the goal of improving clinical outcomes.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Lung cancer
- squamous cell carcinoma
- adenocarcinoma
- CEA
- CK5/6 expression
Added entries (persons, corporate bodies, meetings, titles ...)
- Brandén, EvaUppsala universitet,Centrum för klinisk forskning, Gävleborg,Gavle Cent Hosp, Dept Resp Med, S-80187 Gavle, Sweden;Karolinska Inst, Stockholm, Sweden(Swepub:uu)evabr789 (author)
- Kasim, IhsanGavle Cty Hosp, Dept Pathol, Gavle, Sweden (author)
- Wilander, ErikGavle Cty Hosp, Dept Pathol, Gavle, Sweden (author)
- Uppsala universitetCentrum för klinisk forskning, Gävleborg (creator_code:org_t)
Related titles
- In:Anticancer Research: Anticancer Research USA Inc.38:6, s. 3341-33460250-70051791-7530
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