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  • Robles-Zurita, JoseUniv Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland (author)

SCOT : a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-11-13
  • Springer Science and Business Media LLC,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-372445
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372445URI
  • https://doi.org/10.1038/s41416-018-0319-zDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer.METHODS: In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3-8 years. The within-trial cost-effectiveness analysis from a UK health-care perspective is presented using the resource use data, quality of life (EQ-5D-3L), time on treatment (ToT), disease-free survival after treatment (DFS) and overall survival (OS) data. Quality-adjusted partitioned survival analysis and Kaplan-Meier Sample Average Estimator estimated QALYs and costs. Probabilistic sensitivity and subgroup analysis was undertaken.RESULTS: The 3M arm is less costly (-4881; pound 95% CI: -6269; pound -3492) pound and entails (non-significant) QALY gains (0.08; 95% CI: -0.086; 0.230) due to a better significant quality of life. The net monetary benefit was significantly higher in 3M under a wide range of monetary values of a QALY. The subgroup analysis found similar results for patients in the CAPOX regimen. However, for the FOLFOX regimen, 3M had lower QALYs than 6M (not statistically significant).CONCLUSIONS: Overall, 3M dominates 6M with no significant detrimental impact on QALYs. The results provide the economic case that a 3M treatment strategy should be considered a new standard of care.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Boyd, Kathleen A.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland (author)
  • Briggs, Andrew H.Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland (author)
  • Iveson, TimothySouthampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England (author)
  • Kerr, Rachel S.Univ Oxford, Dept Oncol, Oxford, England (author)
  • Saunders, Mark P.Christie Hosp, Manchester, Lancs, England (author)
  • Cassidy, JimUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland (author)
  • Hollander, Niels HenrikZealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark (author)
  • Tabernero, JosepUniv Autonoma Barcelona, CIBERONC, Vall dHebron Univ Hosp, Barcelona, Spain;Univ Autonoma Barcelona, CIBERONC, Inst Oncol VHIO, Barcelona, Spain (author)
  • Segelov, EvaAustralasian Gastrointestinal Trials Grp AGITG, Melbourne, Vic, Australia;Monash Univ, Melbourne, Vic, Australia;Monash Hlth, Melbourne, Vic, Australia (author)
  • Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim (author)
  • Harkin, AndreaUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland (author)
  • Allan, KarenUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland (author)
  • McQueen, JohnUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland (author)
  • Pearson, SarahUniv Oxford, OCTO, Dept Oncol, Oxford, England (author)
  • Waterston, AshitaBeatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland (author)
  • Medley, LouiseRoyal United Hosp, Bath, Avon, England (author)
  • Wilson, CharlesAddenbrookes Hosp, Cambridge, England (author)
  • Ellis, RichardRoyal Cornwall Hosp NHS Trust, Truro, Cornwall, England (author)
  • Essapen, SharadahRoyal Surrey Cty Hosp NHS Fdn Trust, St Lukes Canc Ctr, Guildford, Surrey, England (author)
  • Dhadda, Amandeep S.Castle Hill Hosp, Kingston Upon Hull, N Humberside, England (author)
  • Hughes, RobMt Vernon Canc Ctr, Northwood, Middx, England (author)
  • Falk, StephenBristol Canc Inst, Bristol, Avon, England (author)
  • Raouf, SherifBarking Havering & Redbridge Univ Hosp NHS Trust, Barking, England (author)
  • Rees, CharlotteSouthampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England (author)
  • Olesen, Rene K.Zealand Univ Hosp, Dept Oncol & Palliat Care, Radmandsengen 5, DK-4700 Naestved, Denmark (author)
  • Propper, DavidQueen Mary Univ London, Barts Canc Inst, London, England (author)
  • Bridgewater, JohnUCL, London, England (author)
  • Azzabi, AshrafNewcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England (author)
  • Farrugia, DavidCheltenham Gen Hosp, Gloucestershire Oncol Ctr, Cheltenham, Glos, England (author)
  • Webb, AndrewBrighton & Sussex Univ Hosp Trust, Brighton, E Sussex, England (author)
  • Cunningham, DavidRoyal Marsden, London, England (author)
  • Hickish, TamasBournemouth Univ, Poole Hosp, Bournemouth, Dorset, England (author)
  • Weaver, AndrewOxford Univ Hosp Fdn Trust, Churchill Hosp, Oxford, England (author)
  • Gollins, SimonNorth Wales Canc Treatment Ctr, Rhyl, Wales (author)
  • Wasan, Harpreet S.Imperial Coll London, Hammersmith Hosp, London, England (author)
  • Paul, JamesUniv Glasgow, Inst Canc Sci, Canc Res UK Clin Trials Unit, Glasgow, Lanark, Scotland (author)
  • Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, ScotlandSouthampton Univ Hosp NHS Fdn Trust, Southampton, Hants, England (creator_code:org_t)

Related titles

  • In:British Journal of Cancer: Springer Science and Business Media LLC119:11, s. 1332-13380007-09201532-1827

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