Can pre-diagnostic serum levels of sodium and potassium predict prostate cancer survival?

Ghoshal, ArunangshuKing's Coll London, Translat Oncol & Urol Res, Sch Canc & Pharmaceut Sci, Guys Hosp, 3rd Floor,Bermondsey Wing, London SE1 9RT, England;Tata Mem Hosp, Dept Palliat Med, Bombay 40012, Maharashtra, India (author)

There is evidence that derangement in serum electrolytes like sodium and potassium is associated with increased morbidity and mortality among hospitalized critically ill patients, but their role in the context of cancer survival remains poorly understood. We sought to investigate the association of pre-diagnostic serum sodium and potassium with risk of overall, cancer-specific, and cardiovascular (CV) death among 11,492 men diagnosed with prostate cancer (PCa) from the Swedish AMORIS study. Multivariable Cox proportional hazards regression was used to assess the risk of death by clinical categories of pre-diagnostic serum sodium and potassium. During a mean follow-up of 5.7years, 1649 men died of PCa. Serum levels of sodium were not indicative of PCa-specific or CV death. A weak positive association was found between pre-diagnostic higher serum potassium (>5mEq/L) and overall death [HR: 1.26 (95% CI: 1.01-1.59)] as compared to low/normal levels of clinical cut-offs. The current study did not find strong evidence for a role of electrolytes in PCa mortality. To further disentangle the potential role of electrolytes in cancer development, future studies should use repeated measurement of serum electrolytes. This research project was reviewed and approved by the Stockholm Ethical Committee (Dnr 2010/1:7).

Garmo, HansUppsala universitet,Uppsala kliniska forskningscentrum (UCR),King's Coll London, Translat Oncol & Urol Res, Sch Canc & Pharmaceut Sci, Guys Hosp, 3rd Floor,Bermondsey Wing, London SE1 9RT, England(Swepub:uu)hga27600 (author)
Hammar, NiklasKarolinska Institutet (author)
Jungner, IngmarKarolinska Inst, Clin Epidemiol Unit, Dept Med, SE-17177 Stockholm, Sweden;CALAB Res, SE-17177 Stockholm, Sweden (author)
Malmström, HåkanKarolinska Institutet (author)
Walldius, GöranKarolinska Institutet (author)
Van Hemelrijck, MiekeKingss Coll London, Translat Oncol & Urol Res, Sch Canc & Pharmaceut Sci, Guys Hosp, 3rd Floor,Bermondsey Wing, London SE1 9RT, England;Karolinska Inst, Inst Environm Med, Epidemiol Unit, SE-17177 Stockholm, Sweden (author)
King's Coll London, Translat Oncol & Urol Res, Sch Canc & Pharmaceut Sci, Guys Hosp, 3rd Floor,Bermondsey Wing, London SE1 9RT, England;Tata Mem Hosp, Dept Palliat Med, Bombay 40012, Maharashtra, IndiaUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

By the author/editor: Ghoshal, Arunang ...; Garmo, Hans; Hammar, Niklas; Jungner, Ingmar; Malmström, Håkan; Walldius, Göran; show more...; Van Hemelrijck, ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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