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Complex and monosom...
Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia : A NOPHO-DBH-AML study
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- Bager, Ninna (author)
- Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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- Juul-Dam, Kristian L. (author)
- Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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- Sandahl, Julie D. (author)
- Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark,Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands
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- Abrahamsson, Jonas (author)
- Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Paediat, Gothenburg, Sweden
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- Beverloo, Berna (author)
- Erasmus MC Sophia Childrens Hosp, Dept Cytogenet, Rotterdam, Netherlands
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- de Bont, Eveline S. J. M. (author)
- Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands
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- Ha, Shau-Yin (author)
- Queen Mary Hosp, Hong Kong Paediat Haematol & Oncol Study Grp, Dept Paediat, Hong Kong, Hong Kong, Peoples R China
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- Jahnukainen, Kirsi (author)
- Karolinska Institutet
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- Jonsson, Olafur G. (author)
- Landspital Inn, Dept Paediat, Reykjavik, Iceland
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- Kaspers, Gertjan L. (author)
- Vrije Univ Amsterdam Med Ctr, Paediat Oncol Haematol, Amsterdam, Netherlands;Acad Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands
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- Kovalova, Zhanna (author)
- Childrens Clin Univ Hosp, Dept Paediat, Riga, Latvia
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- Lausen, Birgitte (author)
- Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark
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- De Moerloose, Barbara (author)
- Ghent Univ Hosp, Dept Paediat, Ghent, Belgium
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- Norén-Nyström, Ulrika (author)
- Umea Univ Hosp, Dept Med Biosci, Genet, Umea, Sweden,Umeå University Hospital
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- Palle, Josefine, 1964- (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Saks, Kadri (author)
- SA Tallinna Lastehaigla, Dept Paediat, Tallinn, Estonia
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- Zeller, Bernward (author)
- Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway
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- Kjeldsen, Eigil (author)
- Aarhus Univ Hosp, Dept Cytogenet, Aarhus, Denmark
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- Hasle, Henrik (author)
- Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
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(creator_code:org_t)
- 2018-11-08
- 2018
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 183:4, s. 618-628
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Abstract
Subject headings
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- Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993-2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2.1 and 3.3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1.43, P = 0.03) and overall survival (OS; HR 1.48, P = 0.01). MK was associated with a poor EFS (HR 1.57, P = 0.03) but did not show an inferior OS compared to non-MK patients (HR 1.14, P = 0.62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Acute myeloid leukaemia
- complex karyotype
- monosomal karyotype
- refractory disease
- paediatrics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bager, Ninna
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Juul-Dam, Kristi ...
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Sandahl, Julie D ...
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Abrahamsson, Jon ...
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Beverloo, Berna
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de Bont, Eveline ...
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show more...
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Ha, Shau-Yin
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Jahnukainen, Kir ...
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Jonsson, Olafur ...
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Kaspers, Gertjan ...
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Kovalova, Zhanna
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Lausen, Birgitte
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De Moerloose, Ba ...
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Norén-Nyström, U ...
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Palle, Josefine, ...
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Saks, Kadri
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Zeller, Bernward
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Kjeldsen, Eigil
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Hasle, Henrik
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet