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Complex and monosom...
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Bager, NinnaAarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
(author)
Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia : A NOPHO-DBH-AML study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-11-08
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Wiley,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-372465
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372465URI
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https://doi.org/10.1111/bjh.15587DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169928URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139703320URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993-2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2.1 and 3.3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1.43, P = 0.03) and overall survival (OS; HR 1.48, P = 0.01). MK was associated with a poor EFS (HR 1.57, P = 0.03) but did not show an inferior OS compared to non-MK patients (HR 1.14, P = 0.62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis.
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Juul-Dam, Kristian L.Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
(author)
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Sandahl, Julie D.Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark,Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands
(author)
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Abrahamsson, JonasQueen Silvia Childrens Hosp, Inst Clin Sci, Dept Paediat, Gothenburg, Sweden
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Beverloo, BernaErasmus MC Sophia Childrens Hosp, Dept Cytogenet, Rotterdam, Netherlands
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de Bont, Eveline S. J. M.Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands
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Ha, Shau-YinQueen Mary Hosp, Hong Kong Paediat Haematol & Oncol Study Grp, Dept Paediat, Hong Kong, Hong Kong, Peoples R China
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Jahnukainen, KirsiKarolinska Institutet
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Jonsson, Olafur G.Landspital Inn, Dept Paediat, Reykjavik, Iceland
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Kaspers, Gertjan L.Vrije Univ Amsterdam Med Ctr, Paediat Oncol Haematol, Amsterdam, Netherlands;Acad Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands
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Kovalova, ZhannaChildrens Clin Univ Hosp, Dept Paediat, Riga, Latvia
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Lausen, BirgitteUniv Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark
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De Moerloose, BarbaraGhent Univ Hosp, Dept Paediat, Ghent, Belgium
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Norén-Nyström, UlrikaUmea Univ Hosp, Dept Med Biosci, Genet, Umea, Sweden,Umeå University Hospital(Swepub:umu)kagr0007
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Palle, Josefine,1964-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)jopal516
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Saks, KadriSA Tallinna Lastehaigla, Dept Paediat, Tallinn, Estonia
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Zeller, BernwardOslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway
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Kjeldsen, EigilAarhus Univ Hosp, Dept Cytogenet, Aarhus, Denmark
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Hasle, HenrikAarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
(author)
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Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, DenmarkUniv Med Ctr Groningen, Dept Paediat, Groningen, Netherlands
(creator_code:org_t)
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In:British Journal of Haematology: Wiley183:4, s. 618-6280007-10481365-2141
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Bager, Ninna
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Juul-Dam, Kristi ...
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Sandahl, Julie D ...
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Abrahamsson, Jon ...
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Beverloo, Berna
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de Bont, Eveline ...
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Ha, Shau-Yin
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Jahnukainen, Kir ...
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Jonsson, Olafur ...
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Kaspers, Gertjan ...
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Kovalova, Zhanna
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Lausen, Birgitte
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De Moerloose, Ba ...
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Norén-Nyström, U ...
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Palle, Josefine, ...
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Saks, Kadri
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Zeller, Bernward
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Kjeldsen, Eigil
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Hasle, Henrik
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