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  • Bager, NinnaAarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark (author)

Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia : A NOPHO-DBH-AML study

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-11-08
  • Wiley,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-372465
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372465URI
  • https://doi.org/10.1111/bjh.15587DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169928URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139703320URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Data on occurrence, genetic characteristics and prognostic impact of complex and monosomal karyotype (CK/MK) in children with acute myeloid leukaemia (AML) are scarce. We studied CK and MK in a large unselected cohort of childhood AML patients diagnosed and treated according to Nordic Society for Paediatric Haematology and Oncology (NOPHO)-AML protocols 1993-2015. In total, 800 patients with de novo AML were included. CK was found in 122 (15%) and MK in 41 (5%) patients. CK and MK patients were young (median age 2.1 and 3.3 years, respectively) and frequently had FAB M7 morphology (24% and 22%, respectively). Refractory disease was more common in MK patients (15% vs. 4%) and stem cell transplantation in first complete remission was more frequent (32% vs. 19%) compared with non-CK/non-MK patients. CK showed no association with refractory disease but was an independent predictor of an inferior event-free survival (EFS; hazard ratio [HR] 1.43, P = 0.03) and overall survival (OS; HR 1.48, P = 0.01). MK was associated with a poor EFS (HR 1.57, P = 0.03) but did not show an inferior OS compared to non-MK patients (HR 1.14, P = 0.62). In a large paediatric cohort, we characterized AML with non-recurrent abnormal karyotype and unravelled the adverse impact of CK and MK on prognosis.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Juul-Dam, Kristian L.Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark (author)
  • Sandahl, Julie D.Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark,Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands (author)
  • Abrahamsson, JonasQueen Silvia Childrens Hosp, Inst Clin Sci, Dept Paediat, Gothenburg, Sweden (author)
  • Beverloo, BernaErasmus MC Sophia Childrens Hosp, Dept Cytogenet, Rotterdam, Netherlands (author)
  • de Bont, Eveline S. J. M.Univ Med Ctr Groningen, Dept Paediat, Groningen, Netherlands (author)
  • Ha, Shau-YinQueen Mary Hosp, Hong Kong Paediat Haematol & Oncol Study Grp, Dept Paediat, Hong Kong, Hong Kong, Peoples R China (author)
  • Jahnukainen, KirsiKarolinska Institutet (author)
  • Jonsson, Olafur G.Landspital Inn, Dept Paediat, Reykjavik, Iceland (author)
  • Kaspers, Gertjan L.Vrije Univ Amsterdam Med Ctr, Paediat Oncol Haematol, Amsterdam, Netherlands;Acad Princess Maxima Ctr Paediat Oncol, Utrecht, Netherlands (author)
  • Kovalova, ZhannaChildrens Clin Univ Hosp, Dept Paediat, Riga, Latvia (author)
  • Lausen, BirgitteUniv Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark (author)
  • De Moerloose, BarbaraGhent Univ Hosp, Dept Paediat, Ghent, Belgium (author)
  • Norén-Nyström, UlrikaUmea Univ Hosp, Dept Med Biosci, Genet, Umea, Sweden,Umeå University Hospital(Swepub:umu)kagr0007 (author)
  • Palle, Josefine,1964-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)jopal516 (author)
  • Saks, KadriSA Tallinna Lastehaigla, Dept Paediat, Tallinn, Estonia (author)
  • Zeller, BernwardOslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway (author)
  • Kjeldsen, EigilAarhus Univ Hosp, Dept Cytogenet, Aarhus, Denmark (author)
  • Hasle, HenrikAarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark (author)
  • Aarhus Univ Hosp, Dept Paediat & Adolescent Med, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, DenmarkUniv Med Ctr Groningen, Dept Paediat, Groningen, Netherlands (creator_code:org_t)

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  • In:British Journal of Haematology: Wiley183:4, s. 618-6280007-10481365-2141

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