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High tumour plasma ...
High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B-symptoms
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- Gholiha, Alex R. (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University UppsalaSweden
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- Hollander, Peter (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini,Section of Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital UppsalaSweden
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- Hedström, Gustaf (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University UppsalaSweden
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- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini,Section of Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital UppsalaSweden
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- Molin, Daniel, 1969- (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University UppsalaSweden
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- Smedby, Karin E (author)
- Karolinska Institutet,Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden
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- Hjalgrim, Henrik (author)
- Department of Epidemiology Research, State Serum Institute, Centre for Cancer Research, Danish Cancer Society, Department of Haematology, Copenhagen University Hospital Rigshospitalet, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark,Division of Clinical Epidemiology Department of Medicine Solna Karolinska Institutet Stockholm Sweden
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- Glimelius, Ingrid, 1975- (author)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University UppsalaSweden
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- Amini, Rose-Marie (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini,Section of Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital UppsalaSweden
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- Enblad, Gunilla (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University UppsalaSweden
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(creator_code:org_t)
- 2018-12-02
- 2019
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 184:2, s. 192-201
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Abstract
Subject headings
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- Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti-CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell-infiltration was associated with the presence of B-symptoms (P = 0·028) and advanced stage, IIB-IVB (P = 0·009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (P = 0·013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (P = 0·004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as ≥10%), had a more inferior event-free survival (P = 0·007) and overall survival (P = 0·004) than patients with a low proportion of infiltrating CD138+ plasma cells (<10%), although significance was not maintained in multivariate analysis. In summary, a high proportion of tumour-associated plasma cells in cHL reflect an important component in the microenvironment of cHL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- CD138 plasma cells
- Hodgkin's lymphoma
- IgG4-producing plasma cells
- Syndecan-1
- tumour microenvironment
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gholiha, Alex R.
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Hollander, Peter
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Hedström, Gustaf
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Sundström, Chris ...
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Molin, Daniel, 1 ...
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Smedby, Karin E
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Hjalgrim, Henrik
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Glimelius, Ingri ...
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Amini, Rose-Mari ...
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Enblad, Gunilla
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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British Journal ...
- By the university
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Uppsala University
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Karolinska Institutet