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- Imgenberg-Kreuz, JulianaUppsala universitet,Science for Life Laboratory, SciLifeLab,Reumatologi (author)
Epigenetic alterations in primary Sjogren's syndrome : an overview
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- Elsevier BV,2018
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-373212
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373212URI
- https://doi.org/10.1016/j.clim.2018.04.004DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
Classification
Notes
- Primary Sjogren's syndrome (pSS) is a chronic autoimmune rheumatic disease characterized by inflammation of exocrine glands, mainly salivary and lacrimal glands. In addition, pSS may affect multiple other organs resulting in systemic manifestations. Although the precise etiology of pSS remains elusive, pSS is considered to be a multi factorial disease, where underlying genetic predisposition, environmental factors and epigenetic mechanisms contribute to disease development. Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNAs, may constitute a dynamic link between genome, environment and phenotypic manifestation by their modulating effects on gene expression. A growing body of studies reporting altered epigenetic landscapes in pSS suggests that epigenetic mechanisms play a role in the pathogenesis of pSS, and the reversible nature of epigenetic modifications suggests therapeutic strategies targeting epigenetic dysregulation in pSS. This article reviews our current understanding of epigenetic mechanisms in pSS and discusses implications for novel diagnostic and therapeutic approaches.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
- Primary Sjogren's syndrome (pSS)
- Epigenetics
- DNA methylation
- Histone modification
- Non-coding RNA (ncRNA)
- Interferon (IFN)
Added entries (persons, corporate bodies, meetings, titles ...)
- Sandling, Johanna K.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Reumatologi(Swepub:uu)josan062 (author)
- Nordmark, GunnelUppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)gunnnord (author)
- Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)
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- In:Clinical Immunology: Elsevier BV196, s. 12-201521-66161521-7035
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