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  • Jangamreddy, JaganmohanLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,LV Prasad Eye Inst, India (author)

Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Elsevier,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-373485
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373485URI
  • https://doi.org/10.1016/j.actbio.2018.01.011DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147108URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Correction in: Acta Biomaterialia, Vol. 81, Pages 330-331.DOI: 10.1016/j.actbio.2018.10.009Correction in: Acta Biomaterialia, Vol.88, Pages 556-557.DOI: 10.1016/j.actbio.2019.01.046
  • Funding Agencies|Dept. of Biotechnology-Vinnova Indo-Sweden Collaborative Health Research Project grant; Integrative Regenerative Medicine Centre, Linkoping University; European Cooperation in Science and Technology (EU-COST) [BM1302-25221, BM1302-34283]; Research Foundation - Flanders [FWO - 11ZB315N]; Euronanomed2 (REGENERATE); Funds for Research in Ophthalmology (FRO); MRC program [MR/K000837/1]
  • Short collagen-like peptides (CLPs) are being proposed as alternatives to full-length collagen for use in tissue engineering, on their own as soft hydrogels, or conjugated to synthetic polymer for mechanical strength. However, despite intended clinical use, little is known about their safety and efficacy, mechanism of action or degree of similarity to the full-length counterparts they mimic. Here, we show the functional equivalence of a CLP conjugated to polyethylene glycol (CLP-PEG) to full-length recombinant human collagen in vitro and in promoting stable regeneration of corneal tissue and nerves in a preclinical mini-pig model. We also show that these peptide analogs exerted their pro-regeneration effects through stimulating extracellular vesicle production by host cells. Our results support future use of CLP-PEG implants for corneal regeneration, suggesting the feasibility of these or similar peptide analogs in clinical application in the eye and other tissues.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Haagdorens, Michel K.C.Dept. of Ophthalmology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Antwerp, Belgium; Faculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Antwerp, Belgium,Antwerp Univ Hosp, Belgium; Univ Antwerp, Belgium (author)
  • Mirazul Islam, Mohammad MirazulLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)mohis64 (author)
  • Lewis, PhilipStructural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales CF24 4HQ, UK,Cardiff Univ, Wales (author)
  • Samanta, AyanLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)ayasa03 (author)
  • Fagerholm, PerLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US(Swepub:liu)perfa04 (author)
  • Liszka, AnetaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)aneli97 (author)
  • Kozak Ljunggren, MonikaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)evako84 (author)
  • Buznyk, OleksiyLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)olebu51 (author)
  • Alarcon, Emilio I.Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada,Univ Ottawa, Canada (author)
  • Zakaria, NadiaDept. of Ophthalmology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Antwerp, Belgium; Faculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Antwerp, Belgium,Antwerp Univ Hosp, Belgium; Univ Antwerp, Belgium (author)
  • Meek, Keith M.Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Wales CF24 4HQ, UK,Cardiff Univ, Wales (author)
  • Griffith, MayLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Univ Montreal, Canada; Univ Montreal, Canada(Swepub:liu)maygr76 (author)
  • Linköpings universitetAvdelningen för cellbiologi (creator_code:org_t)

Related titles

  • In:Acta Biomaterialia: Elsevier69, s. 120-1301742-70611878-7568

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