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Effect of Condition...
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Brunstein, Claudio G
(author)
Effect of Conditioning Regimen Dose Reduction in Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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Elsevier BV,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-374009
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374009URI
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https://doi.org/10.1016/j.bbmt.2018.11.005DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140781150URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Data are limited on whether to adjust high-dose chemotherapy before autologous hematopoietic cell transplant (autoHCT) in obese patients. This study explores the effects of dose adjustment on the outcomes of obese patients, defined as body mass index (BMI) ≥ 30 kg/m2. Dose adjustment was defined as a reduction in standard dosing ≥ 20%, based on ideal, reported dosing and actual weights. We included 2 groups of US patients who had received autoHCT between 2008 and 2014. Specifically, we included patients with multiple myeloma (MM, n = 1696) treated with high-dose melphalan and patients with Hodgkin or non-Hodgkin lymphomas (n = 781) who received carmustine, etoposide, cytarabine, and melphalan conditioning. Chemotherapy dose was adjusted in 1324 patients (78%) with MM and 608 patients (78%) with lymphoma. Age, sex, BMI, race, performance score, comorbidity index, and disease features (stage at diagnosis, disease status, and time to transplant) were similar between dose groups. In multivariate analyses for MM, adjusting for melphalan dose and for center effect had no impact on overall survival (P = .894) and treatment-related mortality (TRM) (P = .62), progression (P = .12), and progression-free survival (PFS; P = .178). In multivariate analyses for lymphoma, adjusting chemotherapy doses did not affect survival (P = .176), TRM (P = .802), relapse (P = .633), or PFS (P = .812). No center effect was observed in lymphoma. This study demonstrates that adjusting chemotherapy dose before autoHCT in obese patients with MM and lymphoma does not influence mortality. These results do not support adjusting chemotherapy dose in this population.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Pasquini, Marcelo C
(author)
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Kim, Soyoung
(author)
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Fei, Mingwei
(author)
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Adekola, Kehinde
(author)
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Ahmed, Ibrahim
(author)
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Aljurf, Mahmoud
(author)
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Agrawal, Vaibhav
(author)
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Auletta, Jeffrey J
(author)
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Battiwalla, Minoo
(author)
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Bejanyan, Nelli
(author)
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Bubalo, Joseph
(author)
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Cerny, Jan
(author)
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Chee, Lynette
(author)
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Ciurea, Stefan O
(author)
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Freytes, Cesar
(author)
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Gadalla, Shahinaz M
(author)
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Gale, Robert Peter
(author)
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Ganguly, Siddhartha
(author)
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Hashmi, Shahrukh K
(author)
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Hematti, Peiman
(author)
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Hildebrandt, Gerhard
(author)
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Holmberg, Leona A
(author)
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Lahoud, Oscar B
(author)
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Landau, Heather
(author)
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Lazarus, Hillard M
(author)
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de Lima, Marcos
(author)
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Mathews, Vikram
(author)
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Maziarz, Richard
(author)
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Nishihori, Taiga
(author)
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Norkin, Maxim
(author)
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Olsson, RichardKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)riols677
(author)
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Reshef, Ran
(author)
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Rotz, Seth
(author)
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Savani, Bipin
(author)
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Schouten, Harry C
(author)
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Seo, Sachiko
(author)
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Wirk, Baldeep M
(author)
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Yared, Jean
(author)
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Mineishi, Shin
(author)
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Rogosheske, John
(author)
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Perales, Miguel-Angel
(author)
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Uppsala universitetCentrum för klinisk forskning i Sörmland (CKFD)
(creator_code:org_t)
Related titles
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In:Biology of blood and marrow transplantation: Elsevier BV25:3, s. 480-4871083-87911523-6536
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Brunstein, Claud ...
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Pasquini, Marcel ...
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Kim, Soyoung
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Fei, Mingwei
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Adekola, Kehinde
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Ahmed, Ibrahim
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Aljurf, Mahmoud
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Agrawal, Vaibhav
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Auletta, Jeffrey ...
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Battiwalla, Mino ...
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Bejanyan, Nelli
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Bubalo, Joseph
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Cerny, Jan
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Chee, Lynette
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Ciurea, Stefan O
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Freytes, Cesar
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Gadalla, Shahina ...
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Gale, Robert Pet ...
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Ganguly, Siddhar ...
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Hashmi, Shahrukh ...
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Hematti, Peiman
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Hildebrandt, Ger ...
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Holmberg, Leona ...
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Lahoud, Oscar B
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Landau, Heather
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Lazarus, Hillard ...
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de Lima, Marcos
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Mathews, Vikram
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Maziarz, Richard
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Nishihori, Taiga
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Norkin, Maxim
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Olsson, Richard
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Reshef, Ran
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Rotz, Seth
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Savani, Bipin
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Schouten, Harry ...
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Seo, Sachiko
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Wirk, Baldeep M
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Yared, Jean
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Mineishi, Shin
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Rogosheske, John
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Perales, Miguel- ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Hematology
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Biology of blood ...
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Uppsala University
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Karolinska Institutet