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Effects of free ome...
Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease : A double-blind, randomized, placebo-controlled study
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- Oscarsson, Jan (author)
- AstraZeneca Gothenburg, Pepparedsleden 1, S-43183 Molndal, Sweden
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- Önnerhag, Kristina (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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- Risérus, Ulf, 1967- (author)
- Uppsala University,Uppsala universitet,Klinisk nutrition och metabolism
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- Sunden, Mattias (author)
- AstraZeneca Gothenburg, Pepparedsleden 1, S-43183 Molndal, Sweden
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- Johansson, Lars (author)
- Antaros Med AB, Molndal, Sweden,Antaros Medical AB
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- Jansson, Per-Anders, 1961 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Moris, Linda (author)
- Karolinska Univ Hosp, Karolinska Trial Alliance, Solna, Sweden,Karolinska University Hospital
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- Nilsson, Peter M. (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Eriksson, Jan (author)
- Uppsala University,Uppsala universitet,Klinisk diabetologi och metabolism
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- Lind, Lars (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Journal of Clinical Lipidology. - : Elsevier BV. - 1933-2874 .- 1876-4789. ; 12:6, s. 1390-1403
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Abstract
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- BACKGROUND: Treatment with omega-3 fatty acids and fenofibrates reduces serum triglyceride levels, but few studies have compared the effect of these agents on liver fat. OBJECTIVE: The aim of the EFFECT I trial (NCT02354976) was to determine the effects of free omega-3 carboxylic acids (OM-3CA) and fenofibrate on liver fat in overweight or obese individuals with non-alcoholic fatty liver disease and hypertriglyceridemia. METHODS: Seventy-eight patients were randomized to receive oral doses of 4 g OM-3CA (n = 25), 200 mg fenofibrate (n = 27), or placebo (n = 26) for 12 weeks in a double-blind, parallel-group study. Liver proton density fat fraction (PDFF) and volume, pancreas volume, and adipose tissue volumes were assessed by magnetic resonance imaging. RESULTS: Changes in liver PDFF at 12 weeks were not significantly different across treatment groups (relative changes from baseline: placebo, +4%; OM-3CA, -2%; and fenofibrate, +17%). The common PNPLA3 genetic polymorphism (I148M) did not significantly influence the effects of OM-3CA or fenofibrate on liver PDFF. Fenofibrate treatment significantly increased liver and pancreas volumes vs placebo treatment, and the changes in liver and pancreas volumes were positively correlated (rho 0.45, P = .02). Total liver fat volume increased significantly in patients using fenofibrate vs OM-3CA (+23% vs 3%, P = .04). Compared with OM-3CA, fenofibrate increased total liver fat and liver volume. Serum triglycerides decreased with OM-3CA (-26%, P = .02) and fenofibrate (-38%, P < .001) vs placebo. In contrast to OM-3CA, fenofibrate reduced plasma docosahexaenoic acid levels and increased plasma acetylcarnitine and butyrylcarnitine levels, estimated delta-9 desaturase activity and the concentration of urine F2-isoprostanes. CONCLUSIONS: OM-3CA and fenofibrate reduced serum triglycerides but did not reduce liver fat. Fenofibrate increased total liver volume and total liver fat volume vs OM-3CA, indicating a complex effect of fenofibrate on human hepatic lipid metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Cholesterol
- Fatty liver disease
- Lipoproteins
- Liver
- Non-alcoholic fatty liver disease
- Omega-3 fatty acids
- Pancreas
- PPARs
- Triglycerides
- Cholesterol
- Fatty liver disease
- Lipoproteins
- Liver
- Non-alcoholic fatty liver disease
- Omega-3 fatty acids
- Pancreas
- PPARs
- Triglycerides
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Oscarsson, Jan
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Önnerhag, Kristi ...
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Risérus, Ulf, 19 ...
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Sunden, Mattias
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Johansson, Lars
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Jansson, Per-And ...
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show more...
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Moris, Linda
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Nilsson, Peter M ...
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Eriksson, Jan
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Lind, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Journal of Clini ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg