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Validation of an MP...
Validation of an MPC polymer coating to attenuate surface- induced cross-talk between the complement and coagulation systems in whole blood in in vitro and in vivo models
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- Asif, Sana, M.D, PhD student (author)
- Uppsala universitet,Klinisk immunologi,Nilsson,Uppsala University, Sweden
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- Asawa, Kenta (author)
- Department of Bioengineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo, 113–8656 Japan,Univ Tokyo, Japan
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- Yuuki, Inoue (author)
- Department of Bioengineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo, 113–8656 Japan,Univ Tokyo, Japan
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- Ishihara, Kazuhiko (author)
- Department of Bioengineering, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo, 113–8656 Japan,Univ Tokyo, Japan
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- Lindell, Björn (author)
- Uppsala universitet,Käkkirurgi,Institutionen för immunologi, genetik och patologi,Uppsala University, Sweden
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- Holmgren, Robin (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala University, Sweden
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- Nilsson, Bo (author)
- Uppsala universitet,Klinisk immunologi,Uppsala University, Sweden
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- Rydén, Anneli (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Jensen Waern, Marianne (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Teramura, Yuji (author)
- Uppsala universitet,Klinisk immunologi,Department of Bioengineering, The University of Tokyo, Tokyo, Japan,Uppsala University, Sweden;Univ Tokyo, Japan
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- Nilsson Ekdahl, Kristina (author)
- Linnéuniversitetet,Uppsala universitet,Klinisk immunologi,Linnaeus Center of Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden,Institutionen för kemi och biomedicin (KOB),Avancerade material,Uppsala University, Sweden,Linnaeus Ctr Biomat Chem, BMC
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(creator_code:org_t)
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- 2019-02-20
- 2019
- English.
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In: Macromolecular Bioscience. - : Wiley-VCH Verlagsgesellschaft. - 1616-5187 .- 1616-5195. ; 19:5
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://res.slu.se/i...
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Abstract
Subject headings
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- Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model. The stability of the coatings is investigated in vitro and MPC polymer-coated catheters are tested in vivo by insertion into the external jugular vein of pigs to monitor the catheters' antithrombotic properties. There is no significant activation of platelets or of the coagulation and complement systems in the MPC polymer-coated one, which was superior in hemocompatibility to non-coated matrix surfaces. The protective effect of the MPC polymer coat does not decline after incubation in human plasma for up to 2 weeks. With MPC polymer-coated catheters, it is possible to easily draw blood from pig for 4 days in contrast to the case for non-coated catheters, in which substantial clotting is seen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- blood compatibility
- blood model systems
- coagulation system
- complement system
- heparin coat
- MPC polymer coat
- Immunologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Asif, Sana, M.D, ...
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Asawa, Kenta
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Yuuki, Inoue
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Ishihara, Kazuhi ...
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Lindell, Björn
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Holmgren, Robin
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Nilsson, Bo
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Rydén, Anneli
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Jensen Waern, Ma ...
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Teramura, Yuji
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Nilsson Ekdahl, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
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NATURAL SCIENCES
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and Immunology
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- Articles in the publication
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Macromolecular B ...
- By the university
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Uppsala University
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Linnaeus University
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Swedish University of Agricultural Sciences