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Unmet Needs in Appendiceal Neuroendocrine Neoplasms

Toumpanakis, Christos (author)
Royal Free Hosp, Neuroendocrine Tumour Unit, London, England
Fazio, Nicola (author)
European Inst Oncol, Div Gastrointestinal Med Oncol & Neuroendocrine T, IEO, Milan, Italy
Tiensuu Janson, Eva (author)
Uppsala universitet,Onkologisk endokrinologi
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Hörsch, Dieter (author)
Ctr Neuroendocrine Tumors Bad Berka, Bad Berka, Germany
Pascher, Andreas (author)
Charite Univ Med Berlin, Campus Virchow Klinikum, Campus Charite Mitte, Dept Surg, Berlin, Germany
Reed, Nicholas (author)
Gartnavel Royal Hosp, Beatson Oncol Ctr, Glasgow, Lanark, Scotland
O'Toole, Dermot (author)
St James Hosp, Trinity Coll Dublin, Dept Clin Med, Dublin, Ireland
Nieveen van Dijkum, Els (author)
Univ Amsterdam, Acad Med Ctr, Dept Surg, Amsterdam, Netherlands
Partelli, Stefano (author)
Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Pancreas Translat & Clin Res Ctr, Pancreat Surg Unit, Milan, Italy
Rinke, Anja (author)
UKGM, Dept Gastroenterol, Marburg, Germany
Kos-Kudla, Beata (author)
Med Univ Silesia, Dept Pathophysiol & Endocrinol, Dept Endocrinol & Neuroendocrine Tumors, Katowice, Poland
Costa, Frederico (author)
Hosp Sirio Libanes, Sao Paulo, Brazil
Pape, Ulrich-Frank (author)
Charite Univ Med Berlin, Div Gastroenterol & Hepatol, Charite Campus Charite Mitte, Med Dept,Campus Virchow Klinikum, Berlin, Germany
Grozinsky-Glasberg, Simona (author)
Hadassah Hebrew Univ, Med Ctr, Dept Endocrinol, Neuroendocrine Tumor Unit, Jerusalem, Israel
Scoazec, Jean-Yves (author)
Gustave Roussy Canc Campus, Dept Pathol, Villejuif, France
Falkerby, Jenny (contributor)
Uppsala universitet,Onkologisk endokrinologi
Sundin, Anders (contributor)
Uppsala universitet,Radiologi
Tiensuu Janson, Eva (contributor)
Uppsala universitet,Onkologisk endokrinologi
Welin, Staffan (contributor)
Uppsala universitet,Onkologisk endokrinologi
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 (creator_code:org_t)
2018-09-20
2019
English.
In: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 108:1, s. 37-44
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered coincidentally during appendicectomy and usually have a benign clinical course; thus, appendicectomy alone is considered curative. However, in some cases, a malignant potential is suspected, and therefore additional operations such as completion right hemicolectomy are considered. The existing European Neuroendocrine Tumour Society (ENETS) guidelines provide useful data about epidemiology and prognosis, as well as practical recommendations with regards to the risk factors for a more aggressive disease course and the indications for a secondary operation. However, these guidelines are based on heterogeneous and retrospective studies. Therefore, the evidence does not seem to be robust, and there are still unmet needs in terms of accurate epidemiology and overall prognosis, optimal diagnostic and follow-up strategy, as well as identified risk factors that would indicate a more aggressive surgical approach at the beginning and a more intense follow-up. In this review, we are adopting a critical approach of the ENETS guidelines and published series for ANEN, focusing on the above-noted "grey areas".

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Appendiceal neuroendocrine neoplasms
Appendicectomy
Appendix
Carcinoids
Right hemicolectomy

Publication and Content Type

ref (subject category)
art (subject category)

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