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Postmortem magnetic...
Postmortem magnetic resonance imaging vs autopsy of second trimester fetuses terminated due to anomalies
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- Hellkvist, Anna (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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- Wikström, Johan, 1964- (author)
- Uppsala universitet,Radiologi
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- Mulic-Lutvica, Ajlana, 1957- (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Ericson, Katharina (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Eriksson-Falkerby, Christopher (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Lindgren, Peter, 1955- (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Center for Fetal Medicine, Karolinska University Hospital, Stockholm, Sweden
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- Penno, Eva (author)
- Uppsala universitet,Radiologi
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- Axelsson, Ove, 1944- (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Obstetrisk och reproduktiv hälsoforskning
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(creator_code:org_t)
- 2019-03-03
- 2019
- English.
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In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 98:7, s. 865-876
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Abstract
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- INTRODUCTION: Our aim was to investigate the accuracy of postmortem fetal magnetic resonance imaging (MRI) compared to fetal autopsy in second trimester pregnancies terminated due to fetal anomalies. A secondary aim was to compare the MRI evaluations of two senior radiologists.MATERIAL AND METHODS: This was a prospective study including 34 fetuses from pregnancies terminated in the second trimester due to fetal anomalies. All women accepted a postmortem MRI and an autopsy of the fetus. Two senior radiologists performed independent evaluations of the MRI images. A senior pathologist performed the fetal autopsies. The degree of concordance between the MRI evaluations and the autopsy reports was estimated as well as the consensus between the radiologists.RESULTS: Thirty-four fetuses were evaluated. Sixteen cases were associated with the central nervous system (CNS), five musculoskeletal, one cardiovascular, one urinary tract, and 11 cases had miscellaneous anomalies such as chromosomal aberrations, infections, and syndromes. In the 16 cases related to the CNS, both radiologists reported all or some, including the most clinically significant anomalies in 15 (94%; CI 70-100%) cases. In the 18 non-CNS cases, both radiologists reported all or some, including the most clinically significant anomalies in six (33%; CI 5-85%) cases. In 21 cases (62%; CI 44-78%) cases, both radiologists held opinions that were consistent with the autopsy reports. The degree of agreement between the radiologists was high, with a Cohen's Kappa of 0.87.CONCLUSIONS: Postmortem fetal MRI can replace autopsy for second trimester fetuses with CNS anomalies. For non-CNS anomalies, the concordance is lower but postmortem MRI can still be of value when autopsy is not an option.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Fetal anomalies
- Fetal diagnosis
- Post-mortem fetal MRI
- Prenatal diagnosis
- Prospective study
- Second trimester
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hellkvist, Anna
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Wikström, Johan, ...
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Mulic-Lutvica, A ...
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Ericson, Kathari ...
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Eriksson-Falkerb ...
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Lindgren, Peter, ...
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Penno, Eva
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Axelsson, Ove, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Acta Obstetricia ...
- By the university
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Uppsala University
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Karolinska Institutet