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Donor Experiences o...
Donor Experiences of Second Marrow or Peripheral Blood Stem Cell Collection Mirror the First, but CD34+ Yields Are Less
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- Stroncek, David F (author)
- Department of Transfusion Medicine, Cell Processing Section, Clinical Center, National Institutes of Health, Bethesda, Maryland
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- Shaw, Bronwen E (author)
- Center for International Blood and Bone Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
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- Logan, Brent R (author)
- Center for International Blood and Bone Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin
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- Kiefer, Deidre M (author)
- Center for International Blood and Bone Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
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- Savani, Bipin N (author)
- Hematology & Stem Cell Transplantation, Vanderbilt University Medical Center, Nashville, Tennessee
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- Anderlini, Paolo (author)
- Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
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- Bredeson, Christopher N (author)
- The Ottawa Hospital Blood & Marrow Transplant Program, University of Ottawa, Ottawa, Ontario, Canada
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- Hematti, Peiman (author)
- Department of Medicine, University of Wisconsin, Madison, Wisconsin
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- Ganguly, Siddhartha (author)
- Hematologic Malignancies and Cellular Therapies, University of Kansas Medical Center, Westwood, Kansas
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- Diaz, Miguel Angel (author)
- Unidad de Trasplante Hematopoyetico, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
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- Abdel-Azim, Hisham (author)
- Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
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- Ahmed, Ibrahim (author)
- Children's Mercy Hospital—UMKC, Kansas City, Missouri
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- Maharaj, Dipnarine (author)
- South Florida Bone Marrow Transplant/Stem Cell Transplant Institute, Bethesda Health City, Boynton Beach, Florida
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- Seftel, Matthew (author)
- Medical Oncology and Haematology, CancerCare Manitoba, Winnipeg, Ontario, Canada
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- Beitinjaneh, Amer (author)
- Stem Cell Transplantation and Cell Therapy Program, Miller School of Medicine, University of Miami, Miami, Florida
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- Seo, Sachiko (author)
- Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington
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- Yared, Jean A (author)
- Department of Medicine, Greenbaum Cancer Center, University of Maryland, Baltimore, Maryland
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- Halter, Joerg (author)
- Department of Haematology, University Hospital Basel, Basel, Switzerland
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- O'Donnell, Paul V (author)
- Blood and Marrow Transplant Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
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- Hale, Gregory A (author)
- Cancer and Blood Disorders Institute, All Children's Hospital, St. Petersburg, Florida
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- DeFilipp, Zachariah (author)
- Blood and Marrow Transplant Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
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- Lazarus, Hillard (author)
- Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
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- Liesveld, Jane L (author)
- Hematology-Oncology Unit, Department of Medicine, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York
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- Zhou, Zheng (author)
- University of Massachusetts, Marlboro, Massachusetts
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- Munshi, Pashna (author)
- Georgetown University Hospital, Washington, District of Columbia
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- Olsson, Richard F. (author)
- Karolinska Institutet
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- Kasow, Kimberly Anne (author)
- Division of Hematology-Oncology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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- Szer, Jeffrey (author)
- Department of Hematology and Bone Marrow Transplantation, Royal Melbourne Hospital City Campus, Victoria, Australia
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- Switzer, Galen E (author)
- Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
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- Chitphakdithai, Pintip (author)
- Center for International Blood and Bone Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
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- Shah, Nirali (author)
- Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
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- Confer, Dennis L (author)
- Center for International Blood and Bone Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota
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- Pulsipher, Michael A (author)
- Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 24:1, s. 175-184
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https://doi.org/10.1...
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http://www.bbmt.org/...
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Abstract
Subject headings
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- Little is known about the experiences of individuals donating peripheral blood stem cells (PBSCs) or marrow for a second time. To study this, unrelated donors making a second donation through the National Marrow Donor Program between 2004 and 2013 were evaluated. Experiences of second-time donors giving marrow (n = 118: first donation was PBSC in 76 and marrow in 42) were compared with those making only 1 marrow donation (n = 5829). Experiences of second-time donors giving PBSCs (n = 602) (first donation was PBSCs in 362; marrow in 240) were compared to first-time PBSC donors (n = 16,095). For donors giving a second PBSC or marrow donation there were no significant differences in maximum skeletal pain, maximum symptoms measured by an established modified toxicity criteria, and recovery time compared with those who donated only once. Notably, the yield of marrow nucleated cells and PBSC CD34+ cells with second donations was less. As previously noted with single first-time donations, female (PBSCs and marrow) and obese donors (PBSCs) had higher skeletal pain and/or toxicity with a second donation. PBSC donors who experienced high levels of pain or toxicity with the first donation also experienced high levels of these symptoms with their second donation and slower recovery times. In conclusion, for most donors second donation experiences were similar to first donation experiences, but CD34+ yields were less. Knowledge of the donor's first experience and stem cell yields may help centers decide whether second donations are appropriate and institute measures to improve donor experiences.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Bone marrow
- Hematopoietic cell transplantation
- Peripheral blood stem cells
- Unrelated donor
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stroncek, David ...
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Shaw, Bronwen E
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Logan, Brent R
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Kiefer, Deidre M
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Savani, Bipin N
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Anderlini, Paolo
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show more...
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Bredeson, Christ ...
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Hematti, Peiman
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Ganguly, Siddhar ...
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Diaz, Miguel Ang ...
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Abdel-Azim, Hish ...
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Ahmed, Ibrahim
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Maharaj, Dipnari ...
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Seftel, Matthew
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Beitinjaneh, Ame ...
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Seo, Sachiko
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Yared, Jean A
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Halter, Joerg
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O'Donnell, Paul ...
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Hale, Gregory A
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DeFilipp, Zachar ...
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Lazarus, Hillard
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Liesveld, Jane L
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Zhou, Zheng
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Munshi, Pashna
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Olsson, Richard ...
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Kasow, Kimberly ...
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Szer, Jeffrey
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Switzer, Galen E
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Chitphakdithai, ...
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Shah, Nirali
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Confer, Dennis L
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Pulsipher, Micha ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Biology of blood ...
- By the university
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Uppsala University
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Karolinska Institutet