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ADAMTS13 protects m...
ADAMTS13 protects mice against renal ischemia-reperfusion injury by reducing inflammation and improving endothelial function
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- Zhou, Suhan (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Jiang, Shan (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Guo, Jie (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Xu, Nan (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Wang, Qin (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Zhang, Gensheng (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Zhao, Liang (author)
- Guangzhou Med Univ, Sch Basic Med Sci, Dept Physiol, Guangzhou, Guangdong, Peoples R China; Charite Univ Med Berlin, Inst Vegetat Physiol, Berlin, Germany
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- Zhou, Qin (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1,Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China
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- Fu, Xiaodong (author)
- Guangzhou Med Univ, Sch Basic Med Sci, Dept Physiol, Guangzhou, Guangdong, Peoples R China
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- Li, Lingei (author)
- Georgetown Univ, Div Nephrol & Hypertens, Washington, DC USA;Georgetown Univ, Hypertens Res Ctr, Washington, DC USA
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- Patzak, Andreas (author)
- Charite Univ Med Berlin, Inst Vegetat Physiol, Berlin, Germany
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- Hultström, Michael, 1978- (author)
- Uppsala universitet,Integrativ Fysiologi,Anestesiologi och intensivvård
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- Lai, En Yin (author)
- Zhejiang Univ, Sch Med, Sch Basic Med Sci, Affiliated Hosp 1, Kidney Dis Ctr, Hangzhou 310003, Zhejiang, Peoples R China;Zhejiang Univ, Sch Med, Sch Basic Med Sci, Dept Physiol, Hangzhou 310003, Zhejiang, Peoples R China; Georgetown Univ, Div Nephrol & Hypertens, Washington, DC USA;Georgetown Univ, Hypertens Res Ctr, Washington, DC USA
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(creator_code:org_t)
- American Physiological Society, 2019
- 2019
- English.
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In: American Journal of Physiology - Renal Physiology. - : American Physiological Society. - 1931-857X .- 1522-1466. ; 316:1, s. F134-F145
- Related links:
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https://journals.phy...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Acute kidney injury (AKI) is a serious condition without efficient therapeutic options. Recent studies have indicated that recombinant human a disintegrin and metalloprotease with thrombospondin motifs 13 (rhADAMTS13) provides protection against inflammation. Therefore, we hypothesized that ADAMTS13 might protect against AKI by reducing inflammation. Bilateral renal ischemia-reperfusion injury (I/R) was used as AKI models in this study. Prophylactic infusion of rhADAMTS13 was employed to investigate potential mechanisms of renal protection. Renal function, inflammation, and microvascular endothelial function were assessed after 24 h of reperfusion. Our results showed that I/R mice increased plasma von Willebrand factor levels but decreased ADAMTS13 expression. Administration of rhADAMTS13 to I/R mice recovered renal function, histological injury, and apoptosis. Renal inflammation was reduced by rhADAMTS13, accompanied with the downregulation of p38/extracellular signal-regulated protein kinase phosphorylation and cyclooxygenase-2 expression. rhADAMTS13 restored vasodilation in afferent arterioles in I/R mice. Furthermore, rhADAMTS13 treatment enhanced phosphorylation of Akt at Set(473) and eNOS at Ser(1177). Administration of the Akt pathway inhibitor wortmannin reduced the protective effect of rhADAMTS13. Our conclusions are that treatment with rhADAMTS13 ameliorates renal I/R injury by reducing inflammation, tubular cell apoptosis. and improving microvascular endothelial dysfunction. rhADAMIS13 could be a promising strategy to treat AKI in clinical settings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- acute kidney injury
- endothelial dysfunction
- ischemia and reperfusion
- rhADAMTS13
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhou, Suhan
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Jiang, Shan
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Guo, Jie
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Xu, Nan
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Wang, Qin
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Zhang, Gensheng
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show more...
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Zhao, Liang
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Zhou, Qin
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Fu, Xiaodong
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Li, Lingei
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Patzak, Andreas
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Hultström, Micha ...
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Lai, En Yin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University