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Neuron-specific ina...
Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord
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- Schnerwitzki, Danny (författare)
- Fritz Lipmann Inst, Leibniz Inst Aging, Mol Genet Lab, Jena, Germany
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- Perry, Sharn (författare)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Ivanova, Anna (författare)
- Fritz Lipmann Inst, Leibniz Inst Aging, Mol Genet Lab, Jena, Germany
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- Caixeta, Fabio V. (författare)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Cramer, Paul (författare)
- Fritz Lipmann Inst, Leibniz Inst Aging, Mol Genet Lab, Jena, Germany
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- Guenther, Sven (författare)
- Fritz Lipmann Inst, Leibniz Inst Aging, Mol Genet Lab, Jena, Germany
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- Weber, Kathrin (författare)
- Fritz Lipmann Inst, Leibniz Inst Aging, Mol Genet Lab, Jena, Germany
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- Tafreshiha, Atieh (författare)
- Uppsala universitet,Fysiologi
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- Becker, Lore (författare)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Expt Genet, German Mouse Clin, Neuherberg, Germany
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- Panesso, Ingrid L. Vargas (författare)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Expt Genet, German Mouse Clin, Neuherberg, Germany;Ludwig Maximilian Univ Munich, Friedrich Baur Inst, Dept Neurol, Munich, Germany
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- Klopstock, Thomas (författare)
- Ludwig Maximilian Univ Munich, Friedrich Baur Inst, Dept Neurol, Munich, Germany;German Ctr Neurodegenerat Dis, Munich, Germany;Ludwig Maximilian Univ Munich, Adolf Butenandt Inst, Munich Cluster Syst Neurol, Munich, Germany;Univ Hosp Munich, German Ctr Vertigo & Balance Disorders, Campus Grosshadern, Munich, Germany
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- de Angelis, Martin Hrabe (författare)
- Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Expt Genet, German Mouse Clin, Neuherberg, Germany;Tech Univ Munich, Sch Life Sci Weihenstephan, Chair Expt Genet, Freising Weihenstephan, Germany;German Ctr Diabet Res, Neuherberg, Germany
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- Schmidt, Manuela (författare)
- Friedrich Schiller Univ Jena, Inst Systemat Zool & Evolutionary Biol, Phylet Museum, Jena, Germany
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- Kullander, Klas, 1966- (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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- Englert, Christoph (författare)
- Fritz Lipmann Inst, Leibniz Inst Aging, Mol Genet Lab, Jena, Germany;Friedrich Schiller Univ Jena, Inst Biochem & Biophys, Jena, Germany
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(creator_code:org_t)
- 2018-08-16
- 2018
- Engelska.
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Ingår i: Life Science Alliance. - : Life Science Alliance, LLC. - 2575-1077. ; 1:4
- Relaterad länk:
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https://doi.org/10.2...
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https://uu.diva-port... (primary) (Raw object)
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https://www.life-sci...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Locomotion is coordinated by neuronal circuits of the spinal cord. Recently, dI6 neurons were shown to participate in the control of locomotion. A subpopulation of dI6 neurons expresses the Wilms tumor suppressor gene Wt1. However, the function of Wt1 in these cells is not understood. Here, we aimed to identify behavioral changes and cellular alterations in the spinal cord associated with Wt1 deletion. Locomotion analyses of mice with neuron-specific Wt1 deletion revealed a slower walk with a decreased stride frequency and an increased stride length. These mice showed changes in their fore-/hindlimb coordination, which were accompanied by a loss of contralateral projections in the spinal cord. Neonates with Wt1 deletion displayed an increase in uncoordinated hindlimb movements and their motor neuron output was arrhythmic with a decreased frequency. The population size of dI6, V0, and V2a neurons in the developing spinal cord of conditional Wt1 mutants was significantly altered. These results show that the development of particular dI6 neurons depends on Wt1 expression and that loss of Wt1 is associated with alterations in locomotion.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (ämneskategori)
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Schnerwitzki, Da ...
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Perry, Sharn
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Ivanova, Anna
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Caixeta, Fabio V ...
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Cramer, Paul
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Guenther, Sven
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visa fler...
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Weber, Kathrin
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Tafreshiha, Atie ...
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Becker, Lore
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Panesso, Ingrid ...
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Klopstock, Thoma ...
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de Angelis, Mart ...
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Schmidt, Manuela
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Kullander, Klas, ...
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Englert, Christo ...
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och Neurovetenskaper
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Uppsala universitet