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FältnamnIndikatorerMetadata
00018054naa a2201777 4500
001oai:DiVA.org:uu-377367
003SwePub
008190219s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-155372
009oai:prod.swepub.kib.ki.se:140184987
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3773672 URI
024a https://doi.org/10.1371/journal.pmed.10027242 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1553722 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1401849872 URI
040 a (SwePub)uud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Johansson, Mattiasu IARC, Lyon, France4 aut
2451 0a The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study
264 c 2019-01-03
264 1b Public Library of Science (PLoS),c 2019
338 a electronic2 rdacarrier
520 a Background: Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation.Methods and findings: Genetic markers associated with obesity measures, blood pressure, lipids, type 2 diabetes, insulin, and glucose were initially identified as instrumental variables, and their association with RCC risk was subsequently evaluated in a genome-wide association study (GWAS) of 10,784 RCC patients and 20,406 control participants in a 2-sample MR framework. The effect on RCC risk was estimated by calculating odds ratios (ORSD) for a standard deviation (SD) increment in each risk factor. The MR analysis indicated that higher body mass index increases the risk of RCC (ORSD: 1.56, 95% confidence interval [CI] 1.44–1.70), with comparable results for waist-to-hip ratio (ORSD: 1.63, 95% CI 1.40–1.90) and body fat percentage (ORSD: 1.66, 95% CI 1.44–1.90). This analysis further indicated that higher fasting insulin (ORSD: 1.82, 95% CI 1.30–2.55) and diastolic blood pressure (DBP; ORSD: 1.28, 95% CI 1.11–1.47), but not systolic blood pressure (ORSD: 0.98, 95% CI 0.84–1.14), increase the risk for RCC. No association with RCC risk was seen for lipids, overall type 2 diabetes, or fasting glucose.Conclusions: This study provides novel evidence for an etiological role of insulin in RCC, as well as confirmatory evidence that obesity and DBP influence RCC risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
700a Carreras-Torres, Robertu IARC, Lyon, France4 aut
700a Scelo, Ghislaineu IARC, Lyon, France4 aut
700a Purdue, Mark P.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Mariosa, Danielau IARC, Lyon, France4 aut
700a Muller, David C.u Imperial Coll, London, England,Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland4 aut
700a Timpson, Nicolas J.u Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England4 aut
700a Haycock, Philip C.u Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England4 aut
700a Brown, Kevin M.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Wang, Zhaomingu St Jude Childrens Res Hosp, Memphis, TN USA4 aut
700a Ye, Yuanqingu Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX USA4 aut
700a Hofmann, Jonathan N.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Foll, Matthieuu IARC, Lyon, France4 aut
700a Gaborieau, Valerieu IARC, Lyon, France4 aut
700a Machiela, Mitchell J.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Colli, Leandro M.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Li, Pengu IARC, Lyon, France;Max Planck Inst Demog Res, Rostock, Germany4 aut
700a Garnier, Jean-Guillaumeu Ctr Energie Atom & Energies Alternat, Inst Genom, Ctr Natl Genotypage, Evry, France; Ctr Etud Polymorphisme Humain, Fdn Jean Dausset, Paris, France4 aut
700a Blanche, Heleneu Ctr Energie Atom & Energies Alternat, Inst Genom, Ctr Natl Genotypage, Evry, France4 aut
700a Boland, Anneu Ctr Energie Atom & Energies Alternat, Inst Genom, Ctr Natl Genotypage, Evry, France4 aut
700a Burdette, Laurieu NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Prokhortchouk, Egoru Russian Acad Sci, Fed Res Ctr Fundamentals Biotechnol, Moscow, Russia4 aut
700a Skryabin, Konstantin G.u Russian Acad Sci, Fed Res Ctr Fundamentals Biotechnol, Moscow, Russia; Kurchatov Sci Ctr, Moscow, Russia4 aut
700a Yeager, Meredithu NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Radojevic-Skodric, Sanjau Univ Belgrade Sch Med, Inst Pathol, Belgrade, Serbia; Clin Ctr Serbia, Clin Urol, Belgrade, Serbia4 aut
700a Ognjanovic, Simonau Mayo Clin, Grad Sch Biomed Sci, Rochester, MN USA; IOCPR, Belgrade, Serbia4 aut
700a Foretova, Lenkau Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic4 aut
700a Holcatova, Ivanau Charles Univ Prague, Fac Med 2, Inst Publ Hlth & Prevent Med, Prague, Czech Republic4 aut
700a Janout, Vladimiru Palacky Univ, Fac Med, Dept Prevent Med, Olomouc, Czech Republic4 aut
700a Mates, Danau Natl Inst Publ Hlth, Bucharest, Romania,IARC, Lyon, France4 aut
700a Mukeriya, Anushu Russian NN Blokhin Canc Res Ctr, Moscow, Russia4 aut
700a Rascu, Stefanu Carol Davila Univ Med & Pharm, Th Burghele Hosp, Bucharest, Romania4 aut
700a Zaridze, Davidu Russian NN Blokhin Canc Res Ctr, Moscow, Russia4 aut
700a Bencko, Vladimiru Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague, Czech Republic4 aut
700a Cybulski, Cezaryu Karolinska Institutet4 aut
700a Fabianova, Eleonorau Reg Author Publ Hlth Banska Bystr, Banska Bystrica, Slovakia4 aut
700a Jinga, Viorelu Carol Davila Univ Med & Pharm, Th Burghele Hosp, Bucharest, Romania4 aut
700a Lissowska, Jolantau M Sklodowska Curie Canc Ctr, Warsaw, Poland; Inst Oncol, Warsaw, Poland4 aut
700a Lubinski, Janu Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland4 aut
700a Navratilova, Marieu Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic4 aut
700a Rudnai, Peteru Natl Publ Hlth Ctr, Natl Directorate Environm Hlth, Budapest, Hungary4 aut
700a Benhamou, Simoneu INSERM, U946, Paris, France; CNRS, Inst Gustave Roussy, UMR 8200, Villejuif, France4 aut
700a Cancel-Tassin, Geraldineu CeRePP, Paris, France; UPMC Univ Paris 06, Inst Univ Cancerol, GRC 5, Paris, France4 aut
700a Cussenot, Olivieru CeRePP, Paris, France; UPMC Univ Paris 06, Inst Univ Cancerol, GRC 5, Paris, France; Hopitaux Univ Est Parisien Tenon, AP HP, Dept Urol, Paris, France4 aut
700a Weiderpass, Elisabeteu Karolinska Institutet4 aut
700a Ljungberg, Börje,d 1949-u Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden4 aut0 (Swepub:umu)bolj0001
700a Tumkur Sitaram, Raviprakash,d 1974-u Umeå universitet,Urologi och andrologi,Umeå Univ, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden4 aut0 (Swepub:umu)tura0001
700a Häggström, Christelu Umeå universitet,Uppsala universitet,Endokrinkirurgi,Umeå Univ, Dept Biobank Res, Umeå, Sweden,Enheten för biobanksforskning,Department of Surgical Sciences, Uppsala University, Sweden4 aut0 (Swepub:umu)chlham02
700a Bruinsma, Fionau Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia4 aut
700a Jordan, Susan J.u QIMR Berghofer Med Res Inst, Herston, Qld, Australia; Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia4 aut
700a Severi, Gianlucau Univ Paris Saclay, Univ Paris Sud, Hlth Generat Team, CESP,INSERM,Fac Med,UVSQ,Gustave Roussy, Villejuif, France; Human Genet Fdn HuGeF, Turin, Italy4 aut
700a Winship, Ingridu Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic, Australia4 aut
700a Hveem, Kristianu Norwegian Univ Sci & Technol, Dept Publ Hlth, KG Jebsen Ctr Genet Epidemiol, Trondheim, Norway4 aut
700a Vatten, Lars J.u Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth & Gen Practice, Trondheim, Norway4 aut
700a Fletcher, Tonyu Univ London, London Sch Hyg & Trop Med, London, England4 aut
700a Larsson, Susanna C.u Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut
700a Wolk, Alicjau Karolinska Institutet4 aut
700a Banks, Rosamonde E.u Univ Leeds, St Jamess Univ Hosp, Leeds Inst Canc & Pathol, Leeds, W Yorkshire, England4 aut
700a Selby, Peter J.u Imperial Coll London, St Marys Hosp, Div Surg, Natl Inst Hlth Res Diagnost Evidence Cooperat, London, England4 aut
700a Easton, Douglas F.u Univ Cambridge, Dept Oncol, Cambridge, England; Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England4 aut
700a Andreotti, Gabriellau NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 aut
700a Freeman, Laura E. Beaneu NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Koutros, Stellau NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Mannisto, Satuu Natl Inst Hlth & Welf, Helsinki, Finland4 aut
700a Weinstein, Stephanieu NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Clark, Peter E.u Vanderbilt Ingram Canc Ctr, Nashville, TN USA4 aut
700a Edwards, Todd L.u Vanderbilt Genet Inst, Vanderbilt Ingram Canc Ctr, Div Epidemiol, Dept Med, Nashville, TN USA4 aut
700a Lipworth, Lorenu Vanderbilt Ingram Canc Ctr, Nashville, TN USA,Amer Canc Soc, Atlanta, GA 30329 USA,Dana Farber Canc Inst, Boston, MA 02115 USA,Van Andel Res Inst, Ctr Canc Genom & Quantitat Biol, Grand Rapids, MI USA; Spectrum Hlth, Grand Rapids, MI USA,Fred Hutchinson Canc Res Ctr, WHI Clin Coordinating Ctr, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700a Gapstur, Susan M.u Amer Canc Soc, Atlanta, GA 30329 USA4 aut
700a Stevens, Victoria L.u Amer Canc Soc, Atlanta, GA 30329 USA4 aut
700a Carol, Hallieu Dana Farber Canc Inst, Boston, MA 02115 USA4 aut
700a Freedman, Matthew L.u Dana Farber Canc Inst, Boston, MA 02115 USA4 aut
700a Pomerantz, Mark M.u Dana Farber Canc Inst, Boston, MA 02115 USA4 aut
700a Cho, Eunyoungu Brown Univ, Providence, RI 02912 USA4 aut
700a Wilson, Kathryn M.u Harvard TH Chan Sch Publ Hlth, Boston, MA USA4 aut
700a Gaziano, J. Michaelu Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA4 aut
700a Sesso, Howard D.u Harvard TH Chan Sch Publ Hlth, Boston, MA USA; Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA4 aut
700a Freedman, Neal D.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Parker, Alexander S.u Mayo Clin, Dept Hlth Sci Res, Jacksonville, FL 32224 USA4 aut
700a Eckel-Passow, Jeanette E.u Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA4 aut
700a Huang, Wen-Yiu NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Kahnoski, Richard J.u Spectrum Hlth, Div Urol, Grand Rapids, MI USA4 aut
700a Lane, Brian R.u Spectrum Hlth, Div Urol, Grand Rapids, MI USA; Michigan State Univ, Coll Human Med, Grand Rapids, MI USA4 aut
700a Noyes, Sabrina L.u Van Andel Res Inst, Ctr Canc Genom & Quantitat Biol, Grand Rapids, MI USA; Spectrum Hlth, Grand Rapids, MI USA4 aut
700a Petillo, Davidu Van Andel Res Inst, Ctr Canc Genom & Quantitat Biol, Grand Rapids, MI USA; Ferris State Univ, Diagnost Program, Grand Rapids, MI USA4 aut
700a Teh, Bin Teanu Van Andel Res Inst, Ctr Canc Genom & Quantitat Biol, Grand Rapids, MI USA; Natl Univ Singapore, Med Sch, Program Canc & Stem Cell Biol, Duke Natl, Singapore, Singapore; ASTAR, Inst Mol & Cell Biol, Singapore, Singapore; Natl Canc Ctr Singapore, Div Med Sci, Lab Canc Epigenome, Singapore, Singapore; Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore4 aut
700a Peters, Ulrikeu Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700a White, Emilyu Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700a Anderson, Garnet L.u Fred Hutchinson Canc Res Ctr, WHI Clin Coordinating Ctr, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700a Johnson, Lisau Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700a Luo, Juhuau Indiana Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Bloomington, IN USA4 aut
700a Buring, Julieu Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA; Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA4 aut
700a Lee, I-Minu Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA; Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA4 aut
700a Chow, Wong-Hou Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA4 aut
700a Moore, Lee E.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Eisen, Timothyu Univ Cambridge, Cambridge, England4 aut
700a Henrion, Marcu Inst Canc Res, London, England; Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA4 aut
700a Larkin, Jamesu Royal Marsden NHS Fdn Trust, London, England4 aut
700a Barman, Poulamiu Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA4 aut
700a Leibovich, Bradley C.u Mayo Clin, Dept Urol, Rochester, MN USA4 aut
700a Choueiri, Toni K.u Dana Farber Canc Inst, Boston, MA 02115 USA4 aut
700a Lathrop, G. Marku McGill Univ, Montreal, PQ, Canada;Genome Quebec Innovat Ctr, Montreal, PQ, Canada,IARC, Lyon, France4 aut
700a Deleuze, Jean-Francoisu Ctr Energie Atom & Energies Alternat, Inst Genom, Ctr Natl Genotypage, Evry, France; Ctr Etud Polymorphisme Humain, Fdn Jean Dausset, Paris, France4 aut
700a Gunter, Marcu IARC, Lyon, France4 aut
700a McKay, James D.u IARC, Lyon, France4 aut
700a Wu, Xifengu Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA4 aut
700a Houlston, Richard S.u Inst Canc Res, London, England4 aut
700a Chanock, Stephen J.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA4 aut
700a Relton, Carolineu Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England; Univ Bristol, Sch Social & Community Med, Bristol, Avon, England4 aut
700a Richards, J. Brentu McGill Univ, Jewish Gen Hosp, Dept Med, Montreal, PQ, Canada;McGill Univ, Jewish Gen Hosp, Dept Human Genet, Montreal, PQ, Canada;McGill Univ, Jewish Gen Hosp, Dept Epidemiol & Biostat, Montreal, PQ, Canada4 aut
700a Martin, Richard M.u Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England; Univ Bristol, Sch Social & Community Med, Bristol, Avon, England; Univ Bristol, Univ Hosp Bristol NHS Fdn Trust, Natl Inst Hlth Res, Bristol Nutr Biomed Res Unit, Bristol, Avon, England4 aut
700a Smith, George Daveyu Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England; Univ Bristol, Sch Social & Community Med, Bristol, Avon, England4 aut
700a Brennan, Paulu IARC, Lyon, France4 aut
710a IARC, Lyon, Franceb NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD USA4 org
773t PLoS Medicined : Public Library of Science (PLoS)g 16:1q 16:1x 1549-1277x 1549-1676
856u https://doi.org/10.1371/journal.pmed.1002724y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1289953/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002724&type=printable
856u https://umu.diva-portal.org/smash/get/diva2:1278532/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-377367
8564 8u https://doi.org/10.1371/journal.pmed.1002724
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155372
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140184987

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