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Modeling and Targeting MYC Genes in Childhood Brain Tumors
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- Hutter, Sonja (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Bolin, Sara, 1988- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- Weishaupt, Holger (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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- (creator_code:org_t)
- 2017-03-23
- 2017
- English.
- In: Genes. - : MDPI. - 2073-4425. ; 8:4
- Research review (peer-reviewed)
Abstract
Subject headings
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- Brain tumors are the second most common group of childhood cancers, accounting for about 20%-25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of these neoplasms, and their expression levels are often correlated with poor prognosis. Elevated c-MYC/MYCN initiates and drives tumorigenesis in many in vivo model systems of pediatric brain tumors. Therefore, inhibition of their oncogenic function is an attractive therapeutic target. In this review, we explore the roles of MYC oncoproteins and their molecular targets during the formation, maintenance, and recurrence of childhood brain tumors. We also briefly summarize recent progress in the development of therapeutic approaches for pharmacological inhibition of MYC activity in these tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MYC
- oncogene
- pediatric brain tumors
- targeted therapy
- medulloblastoma
- glioma
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