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  • Manell, HannesUppsala universitet,Institutionen för kvinnors och barns hälsa,Institutionen för medicinsk cellbiologi (author)

Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity and impaired glucose tolerance

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-07-17
  • Hindawi Limited,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-380313
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380313URI
  • https://doi.org/10.1111/pedi.12890DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective: To delineate mechanisms for fasting hyperglucagonemia in childhood obesity bystudying the associations between fasting plasma glucagon concentrations and plasmalipid parameters and fat compartments.Methods: Cross-sectional study of children and adolescents with obesity (n=147) and leancontrols (n=43). Differences in free fatty acids (FFA), triglycerides, insulin and fatcompartments (quantified by magnetic resonance imaging) across quartiles of fastingplasma glucagon concentration were analysed. Differences in OGTT glucagonresponse was tested in high vs low FFAs, triglycerides and insulin. Human islets ofLangerhans were cultured at 5.5 mmol/l glucose and in the absence or presence of aFFA mixture with total FFA concentration of 0.5 mmol/l and glucagon secretionquantified.Results: In children with obesity, the quartile with the highest fasting glucagon had higherinsulin (201±174 vs 83±39 pmol/l, p<0.01), FFAs (383±52 vs 338±109 μmol/l,p=0.02), triglycerides (1.5±0.9 vs 1.0±0.7 mmol/l, p<0.01), visceral adipose tissuevolume (1.9±0.8 vs 1.2±0.3 dm3, p<0.001) and a higher prevalence of impairedglucose tolerance (41% vs 8%, p=0.01) than the lowest quartile. During OGTT,children with obesity and high insulin had a worse suppression of glucagon during thefirst 10 minutes after glucose intake. Glucagon secretion was 2.6-fold higher in isletstreated with FFAs than in those not treated with FFAs.4Conclusion: Hyperglucagonemia in childhood obesity is associated with hyperinsulinemia, highplasma FFAs, high plasma triglycerides, visceral adiposity and impaired glucosetolerance. The glucagonotropic effect of FFAs on isolated human islets provides apotential mechanism linking high fasting plasma FFAs and glucagon levels.

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  • Kristinsson, HjaltiUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)hjakr151 (author)
  • Kullberg, Joel,1979-Uppsala universitet,Radiologi(Swepub:uu)jokul377 (author)
  • Ubhayasekera, Sarojini Jayantha KumariUppsala universitet,Analytisk kemi(Swepub:uu)kumub884 (author)
  • Mörwald, KatharinaParacelsus Medical University (author)
  • Staaf, JohanUppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa(Swepub:uu)johst547 (author)
  • Cadamuro, JanneParacelsus Medical University (author)
  • Zsoldos, FanniParacelsus Medical University (author)
  • Göpel, SvenAstraZeneca (author)
  • Sargsyan, ErnestUppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)ernsa357 (author)
  • Ahlström, Håkan,1953-Uppsala universitet,Radiologi(Swepub:uu)hakanahl (author)
  • Bergquist, JonasUppsala universitet,Analytisk kemi(Swepub:uu)jbe25356 (author)
  • Weghuber, DanielParacelsus Medical University (author)
  • Forslund, Anders,1961-Uppsala universitet,Pediatrisk inflammationsforskning(Swepub:uu)andeforsl (author)
  • Bergsten, PeterUppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammationsforskning(Swepub:uu)peteberg (author)
  • Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

Related titles

  • In:Pediatric Diabetes: Hindawi Limited20:7, s. 880-8911399-543X1399-5448

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