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LIPG-promoted lipid...
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
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- Zhang, C. (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Vosbeck, Sonja (author)
- Technische Universität Dortmund
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- Edlund, Karolina (author)
- Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Dortmund, Germany,Technische Universität Dortmund
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- Grgas, Katharina (author)
- Technische Universität Dortmund
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- Madjar, Katrin (author)
- Technische Universität Dortmund
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- Hellwig, Birte (author)
- Technische Universität Dortmund
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- Adawy, Alshaimaa (author)
- Technische Universität Dortmund
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- Glotzbach, Annika (author)
- Technische Universität Dortmund
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- Stewart, Joanna D. (author)
- Technische Universität Dortmund,University of Southampton
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- Lesjak, Michaela S. (author)
- Technische Universität Dortmund
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- Franckenstein, Dennis (author)
- Technische Universität Dortmund
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- Claus, Maren (author)
- Technische Universität Dortmund
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- Hayen, Heiko (author)
- Westfaelische Wilhelms-Universität Münster,University of Münster
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- Schriewer, Alexander (author)
- Westfaelische Wilhelms-Universität Münster,University of Münster
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- Gianmoena, Kathrin (author)
- Technische Universität Dortmund
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- Thaler, Sonja (author)
- Ruprecht-Karls-Universität Heidelberg,Heidelberg University
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Schmidt, Marcus (author)
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- Micke, Patrick (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Uppsala University
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- Pontén, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén,Uppsala University
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- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab
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Zhang, Cheng (author)
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- Käfferlein, Heiko U. (author)
- Ruhr-Universität Bochum
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- Watzl, Carsten (author)
- Technische Universität Dortmund
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- Frank, Saša (author)
- Medizinische Universität Graz,Medical University of Graz
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- Rahnenführer, Jörg (author)
- Technische Universität Dortmund
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- Marchan, Rosemarie (author)
- Technische Universität Dortmund
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- Hengstler, Jan G. (author)
- Technische Universität Dortmund
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Cadenas, Cristina (author)
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(creator_code:org_t)
- 2019-02-07
- 2019
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 145:4, s. 901-915
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high‐density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that severe oxidative stress leading to AMPK activation triggers LIPG upregulation, resulting in intracellular lipid droplet accumulation in breast cancer cells, which supports survival. Neutralizing oxidative stress abrogated LIPG upregulation and the concomitant lipid storage. In human breast cancer, high LIPG expression was observed in a limited subset of tumours and was significantly associated with shorter metastasis‐free survival in node‐negative, untreated patients. Moreover, expression of PLIN2 and TXNRD1 in these tumours indicated a link to lipid storage and oxidative stress. Altogether, our findings reveal a previously unrecognized role for LIPG in enabling oxidative stress‐induced lipid droplet accumulation in tumour cells that protects against oxidative stress, and thus supports tumour progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- LIPG
- PLIN2
- TXNRD1
- breast cancer
- endothelial lipase
- lipid droplets
- oxidative stress
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Zhang, C.
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Vosbeck, Sonja
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Edlund, Karolina
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Grgas, Katharina
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Madjar, Katrin
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Hellwig, Birte
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show more...
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Adawy, Alshaimaa
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Glotzbach, Annik ...
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Stewart, Joanna ...
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Lesjak, Michaela ...
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Franckenstein, D ...
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Claus, Maren
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Hayen, Heiko
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Schriewer, Alexa ...
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Gianmoena, Kathr ...
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Thaler, Sonja
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Schmidt, Marcus
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Micke, Patrick
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Pontén, Fredrik
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Mardinoglu, Adil ...
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Zhang, Cheng
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Käfferlein, Heik ...
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Watzl, Carsten
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Frank, Saša
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Rahnenführer, Jö ...
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Marchan, Rosemar ...
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Hengstler, Jan G ...
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Cadenas, Cristin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Chalmers University of Technology
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Royal Institute of Technology