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  • Zhang, C.KTH,Science for Life Laboratory, SciLifeLab (author)

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-02-07
  • Wiley,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-380591
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380591URI
  • https://doi.org/10.1002/ijc.32138DOI
  • https://research.chalmers.se/publication/511243URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-248699URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20190423
  • Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high‐density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that severe oxidative stress leading to AMPK activation triggers LIPG upregulation, resulting in intracellular lipid droplet accumulation in breast cancer cells, which supports survival. Neutralizing oxidative stress abrogated LIPG upregulation and the concomitant lipid storage. In human breast cancer, high LIPG expression was observed in a limited subset of tumours and was significantly associated with shorter metastasis‐free survival in node‐negative, untreated patients. Moreover, expression of PLIN2 and TXNRD1 in these tumours indicated a link to lipid storage and oxidative stress. Altogether, our findings reveal a previously unrecognized role for LIPG in enabling oxidative stress‐induced lipid droplet accumulation in tumour cells that protects against oxidative stress, and thus supports tumour progression.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vosbeck, SonjaTechnische Universität Dortmund (author)
  • Edlund, KarolinaDepartment of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Dortmund, Germany,Technische Universität Dortmund (author)
  • Grgas, KatharinaTechnische Universität Dortmund (author)
  • Madjar, KatrinTechnische Universität Dortmund (author)
  • Hellwig, BirteTechnische Universität Dortmund (author)
  • Adawy, AlshaimaaTechnische Universität Dortmund (author)
  • Glotzbach, AnnikaTechnische Universität Dortmund (author)
  • Stewart, Joanna D.Technische Universität Dortmund,University of Southampton (author)
  • Lesjak, Michaela S.Technische Universität Dortmund (author)
  • Franckenstein, DennisTechnische Universität Dortmund (author)
  • Claus, MarenTechnische Universität Dortmund (author)
  • Hayen, HeikoWestfaelische Wilhelms-Universität Münster,University of Münster (author)
  • Schriewer, AlexanderWestfaelische Wilhelms-Universität Münster,University of Münster (author)
  • Gianmoena, KathrinTechnische Universität Dortmund (author)
  • Thaler, SonjaRuprecht-Karls-Universität Heidelberg,Heidelberg University (author)
  • Schmidt, Marcus (author)
  • Micke, PatrickUppsala universitet,Klinisk och experimentell patologi,Patrick Micke,Uppsala University(Swepub:uu)patmi676 (author)
  • Pontén, FredrikUppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén,Uppsala University(Swepub:uu)fredpont (author)
  • Mardinoglu, Adil,1982KTH,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1t8kmr6 (author)
  • Zhang, Cheng (author)
  • Käfferlein, Heiko U.Ruhr-Universität Bochum (author)
  • Watzl, CarstenTechnische Universität Dortmund (author)
  • Frank, SašaMedizinische Universität Graz,Medical University of Graz (author)
  • Rahnenführer, JörgTechnische Universität Dortmund (author)
  • Marchan, RosemarieTechnische Universität Dortmund (author)
  • Hengstler, Jan G.Technische Universität Dortmund (author)
  • Cadenas, Cristina (author)
  • KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: Wiley145:4, s. 901-9150020-71361097-0215

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