Relationship between T-cell-dependent and T-cell-independent vaccines after neurotrauma: Can the response be predicted?

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Ljunghill Hedberg, AnnaUppsala universitet,Infektionsmedicin (author)

Relationship between T-cell-dependent and T-cell-independent vaccines after neurotrauma : Can the response be predicted?

Article/chapterEnglish2022

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2022-06-15
Taylor & Francis Group,2022
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-380638
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380638URI
https://doi.org/10.1080/21645515.2022.2088971DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background: After trauma and central nervous system (CNS) injury, trauma-induced immune deficiency syndrome (TIDS) and CNS injury-induced immune deficiency syndrome (CIDS) may negatively affect responses to T-cell-dependent vaccines, such as pneumococcal conjugate vaccine (PCV) recommended after basilar fracture. This study (NCT02806284) aimed to investigate whether there after neurotrauma is a correlation between T-cell-dependent and independent vaccine responses and, thus, if B-cell activity is similarly depressed and whether the T-cell-dependent response is possible to predict.Method: Adult patients with basilar fracture (n = 33) and those undergoing pituitary gland surgery (n = 23) were within 10 days vaccinated with a T-cell-dependent vaccine against Haemophilus influenzae type b (Hib) and a T-cell-independent pneumococcal polysaccharide vaccine (PPSV). Samples reflecting the systemic inflammatory response and pre- and post-vaccination antibody levels after 3–6 weeks against Hib and PPSV were collected and determined by enzyme immunoassays.Results: High and significant correlations were detected in the responses to different pneumococcal serotypes, but none between the Hib and PPSV responses. No differences in trauma scores, C-reactive protein, IL-6, IL-10, pentraxin 3, fractalkine or calprotectin plasma concentrations or in ex vivo TNF-α, IL-6 or IL-10 responses to endotoxin were found between Hib vaccination responders and non-responders.Conclusions: There was no correlation between the pneumococcal responses and that to Hib, indicating that B-cell function is not similarly depressed as T-cell function. Grading of the trauma or parameters reflecting the innate immune response could not predict the T-cell-dependent vaccine response. There is a need of further studies evaluating the vaccine response after neurotrauma.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
Posttraumatic meningitis
pneumococcal polysaccharide vaccine
pneumococcal conjugate vaccine
CNS injury-induced immune deficiency syndrome
T-Cell function
B-Cell function

Added entries (persons, corporate bodies, meetings, titles ...)

Pauksen, KarlisUppsala universitet,Infektionsmedicin(Swepub:uu)karlpauk (author)
Enblad, PerUppsala universitet,Neurokirurgi(Swepub:uu)perenbla (author)
Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (author)
Sjölin, JanUppsala universitet,Infektionsmedicin(Swepub:uu)jasjo255 (author)
Uppsala universitetInfektionsmedicin (creator_code:org_t)

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In:Human Vaccines & Immunotherapeutics: Taylor & Francis Group18:52164-55152164-554X

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