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Predictors of Epile...
Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas
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Zanello, Marc (author)
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Goodden, John R (author)
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Colle, Henry (author)
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Wager, Michel (author)
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De Witt Hamer, Philip C (author)
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- Smits, Anja (author)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Neurologi,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Bello, Lorenzo (author)
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Tate, Matthew (author)
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Spena, Giannantonio (author)
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Bresson, Damien (author)
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Capelle, Laurent (author)
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Robles, Santiago Gil (author)
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Sarubbo, Silvio (author)
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- Rydenhag, Bertil, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Martino, Juan (author)
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Meyer, Bernhard (author)
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Fontaine, Denys (author)
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Reyns, Nicolas (author)
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Schichor, Christian (author)
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Metellus, Philippe (author)
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Colle, David (author)
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Robert, Erik (author)
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Noens, Bonny (author)
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Muller, Peter (author)
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Rossi, Marco (author)
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Nibali, Marco Conti (author)
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Papagno, Costanza (author)
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Galbarritu, Lara (author)
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Ruiz de Gopegui, Edurne (author)
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Chioffi, Franco (author)
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Bucheli, Carlos (author)
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Krieg, Sandro M (author)
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Wostrack, Maria (author)
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Yusupov, Natan (author)
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Visser, Victoria (author)
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Baaijen, Johannes C (author)
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Roux, Alexandre (author)
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Dezamis, Edouard (author)
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Mandonnet, Emmanuel (author)
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Corns, Robert (author)
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Duffau, Hugues (author)
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Pallud, Johan (author)
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(creator_code:org_t)
- 2019-10
- 2019
- English.
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In: Neurosurgery. - : Ovid Technologies (Wolters Kluwer Health). - 0148-396X .- 1524-4040. ; 85:4, s. E702-E713
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- BACKGROUND: The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area.OBJECTIVE: To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery.METHODS: Multicenter international retrospective cohort analysis of adult patients benefitting from a functional-based surgical resection with intraoperative functional brain mapping for a supratentorial CA within or close to eloquent brain areas.RESULTS: A total of 109 patients (66.1% women; mean age 38.4 ± 12.5 yr), were studied. Age >38 yr (odds ratio [OR], 7.33; 95% confidence interval [CI], 1.53-35.19; P = .013) and time to surgery > 12 mo (OR, 18.21; 95% CI, 1.11-296.55; P = .042) are independent predictors of uncontrolled seizures at the time of surgery. Focal deficit (OR, 10.25; 95% CI, 3.16-33.28; P < .001) is an independent predictor of inability to work at the time of surgery. History of epileptic seizures at the time of surgery (OR, 7.61; 95% CI, 1.67-85.42; P = .003) and partial resection of the CA and/or of the hemosiderin rim (OR, 12.02; 95% CI, 3.01-48.13; P < .001) are independent predictors of uncontrolled seizures postoperatively. Inability to work at the time of surgery (OR, 19.54; 95% CI, 1.90-425.48; P = .050), Karnofsky Performance Status ≤ 70 (OR, 51.20; 95% CI, 1.20-2175.37; P = .039), uncontrolled seizures postoperatively (OR, 105.33; 95% CI, 4.32-2566.27; P = .004), and worsening of cognitive functions postoperatively (OR, 13.71; 95% CI, 1.06-176.66; P = .045) are independent predictors of inability to work postoperatively.CONCLUSION: The functional-based resection using intraoperative functional brain mapping allows safe resection of CA and the peripheral hemosiderin rim located within or close to eloquent brain areas.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Cavernous angioma
- Epilepsy
- Intraoperative brain mapping
- Outcome
- Return to work
- Seizures
- Surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zanello, Marc
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Goodden, John R
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Colle, Henry
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Wager, Michel
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De Witt Hamer, P ...
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Smits, Anja
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show more...
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Bello, Lorenzo
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Tate, Matthew
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Spena, Giannanto ...
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Bresson, Damien
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Capelle, Laurent
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Robles, Santiago ...
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Sarubbo, Silvio
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Rydenhag, Bertil ...
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Martino, Juan
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Meyer, Bernhard
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Fontaine, Denys
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Reyns, Nicolas
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Schichor, Christ ...
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Metellus, Philip ...
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Colle, David
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Robert, Erik
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Noens, Bonny
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Muller, Peter
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Rossi, Marco
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Nibali, Marco Co ...
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Papagno, Costanz ...
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Galbarritu, Lara
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Ruiz de Gopegui, ...
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Chioffi, Franco
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Bucheli, Carlos
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Krieg, Sandro M
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Wostrack, Maria
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Yusupov, Natan
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Visser, Victoria
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Baaijen, Johanne ...
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Roux, Alexandre
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Dezamis, Edouard
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Mandonnet, Emman ...
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Corns, Robert
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Duffau, Hugues
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Pallud, Johan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Neurosurgery
- By the university
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Uppsala University
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University of Gothenburg