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Clinical impact of ...
Clinical impact of [18F]flutemetamol PET among memory clinic patients with an unclear diagnosis.
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Leuzy, Antoine (author)
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Savitcheva, Irina (author)
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- Chiotis, Konstantinos (author)
- Karolinska Institutet
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- Lilja, Johan (author)
- Uppsala universitet,Radiologi
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Andersen, Pia (author)
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- Bogdanovic, Nenad (author)
- Karolinska Institutet
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- Jelic, Vesna (author)
- Karolinska Institutet
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- Nordberg, Agneta (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-03-26
- 2019
- English.
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In: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 46:6, s. 1276-1286
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Abstract
Subject headings
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- PURPOSE: To investigate the impact of amyloid PET with [18F]flutemetamol on diagnosis and treatment management in a cohort of patients attending a tertiary memory clinic in whom, despite extensive cognitive assessment including neuropsychological testing, structural imaging, CSF biomarker analysis and in some cases [18F]FDG PET, the diagnosis remained unclear.METHODS: The study population consisted of 207 patients with a clinical diagnosis prior to [18F]flutemetamol PET including mild cognitive impairment (MCI; n = 131), Alzheimer's disease (AD; n = 41), non-AD (n = 10), dementia not otherwise specified (dementia NOS; n = 20) and subjective cognitive decline (SCD; n = 5).RESULTS: Amyloid positivity was found in 53% of MCI, 68% of AD, 20% of non-AD, 20% of dementia NOS, and 60% of SCD patients. [18F]Flutemetamol PET led, overall, to a change in diagnosis in 92 of the 207 patients (44%). A high percentage of patients with a change in diagnosis was observed in the MCI group (n = 67, 51%) and in the dementia NOS group (n = 11; 55%), followed by the non-AD and AD (30% and 20%, respectively). A significant increase in cholinesterase inhibitor treatment was observed after [18F]flutemetamol PET (+218%, 34 patients before and 108 patients after).CONCLUSION: The present study lends support to the clinical value of amyloid PET in patients with an uncertain diagnosis in the tertiary memory clinic setting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Alzheimer’s disease
- Amyloid PET
- Cholinesterase inhibitors
- Diagnostic change
- [18F]Flutemetamol
Publication and Content Type
- ref (subject category)
- art (subject category)
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