PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue

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Lundström, ElinUppsala universitet,Radiologi (author)

PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue

Article/chapterEnglish2021

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2021-07-22
Springer Nature,2021
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LIBRIS-ID:oai:DiVA.org:uu-381764
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-381764URI
https://doi.org/10.1038/s41598-021-87768-wDOI

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Summary in:English

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Title in dissertation list of papers: PET/MRI of glucose uptake, lipid content and perfusion in human brown adipose tissue.
This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MRglu) and changes in lipid content, perfusion and arterial blood volume (V-A) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and V-A were quantified with dynamic [O-15]water-PET, and FF, with water-fat MRI. MRglu was assessed with dynamic [F-18]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBAT(HI), by MRglu>11 mu mol/100 cm(3)/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MRglu (rho <=- 0.87). After 3 h of cold, sBAT-FF decreased (- 2.13 percentage points) but tended to normalize during reheating although sBAT(HI)-FF remained low. sBAT-perfusion and sBAT-V-A increased during cold exposure (perfusion:+5.2 ml/100 cm(3)/min, V-A:+4.0 ml/100 cm(3)). sBAT-perfusion remained elevated and sBAT-V-A normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MRglu. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and V-A, on the changes in FF observed during cold exposure, could not be ruled out.

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Andersson, JonathanUppsala universitet,Radiologi(Swepub:uu)jonan358 (author)
Engström, MathiasGE Healthcare (author)
Lubberink, MarkUppsala universitet,Radiologi,Uppsala Univ Hosp, Med Phys, Uppsala, Sweden.(Swepub:uu)marklubb (author)
Strand, Robin,1978-Uppsala universitet,Avdelningen för visuell information och interaktion,Radiologi(Swepub:uu)rostr275 (author)
Ahlström, Håkan,1953-Uppsala universitet,Radiologi,BioVenture Hub, Antaros Med, Mölndal, Sweden.(Swepub:uu)hakanahl (author)
Kullberg, Joel,1979-Uppsala universitet,Radiologi,BioVenture Hub, Antaros Med, Mölndal, Sweden.(Swepub:uu)jokul377 (author)
Uppsala universitetRadiologi (creator_code:org_t)

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In:Scientific Reports: Springer Nature112045-2322

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