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Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele.

Kennedy, L J (author)
Quarmby, S (author)
Happ, G M (author)
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Barnes, A (author)
Ramsey, I K (author)
Dixon, R M (author)
Catchpole, B (author)
Rusbridge, C (author)
Graham, P A (author)
Salmon Hillbertz, Nicolette (author)
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences
Roethel, C (author)
Dodds, W J (author)
Carmichael, N G (author)
Ollier, W E R (author)
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 (creator_code:org_t)
Wiley, 2006
2006
English.
In: Tissue Antigens. - : Wiley. - 0001-2815 .- 1399-0039. ; 68:1, s. 82-6
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.

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