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Gut microbiota regu...
Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages
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- Suh, Sang Heon (author)
- Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea
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- Choe, Kibaek (author)
- Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Daejeon, South Korea
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- Hong, Seon Pyo (author)
- Inst for Basic Sci Korea, Ctr Vasc Res, Daejeon, South Korea
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- Jeong, Seung-hwan (author)
- Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea
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- Mäkinen, Taija (author)
- Uppsala universitet,Vaskulärbiologi
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- Kim, Kwang Soon (author)
- Inst for Basic Sci Korea, Acad Immunol & Microbiol, Pohang, South Korea
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- Alitalo, Kari (author)
- Univ Helsinki, Biomed Helsinki, Translat Canc Biol Program, Helsinki, Finland;Univ Helsinki, Biomed Helsinki, Wihuri Res Inst, Helsinki, Finland
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- Surh, Charles D. (author)
- Inst for Basic Sci Korea, Acad Immunol & Microbiol, Pohang, South Korea
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- Koh, Gou Young (author)
- Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea;Inst for Basic Sci Korea, Ctr Vasc Res, Daejeon, South Korea
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- Song, Joo-Hye (author)
- Inst for Basic Sci Korea, Ctr Vasc Res, Daejeon, South Korea
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(creator_code:org_t)
- 2019-02-19
- 2019
- English.
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In: EMBO Reports. - : WILEY. - 1469-221X .- 1469-3178. ; 20:4
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Germ depletion by antibiotic treatment triggers lacteal regression during adulthood and delays lacteal maturation during the postnatal period. In accordance with compromised lipid absorption, the button-like junction between lymphatic endothelial cells, which is ultrastructurally open to permit free entry of dietary lipids into lacteals, is significantly reduced in lacteals of germ-depleted mice. Lacteal defects are also found in germ-free mice, but conventionalization of germ-free mice leads to normalization of lacteals. Mechanistically, VEGF-C secreted from villus macrophages upon MyD88-dependent recognition of microbes and their products is a main factor in lacteal integrity. Collectively, we conclude that the gut microbiota is a crucial regulator for lacteal integrity by endowing its unique microenvironment and regulating villus macrophages in small intestine.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- intestinal lymphatic vasculature
- lacteal
- macrophage
- microbiota
- VEGF-C
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Suh, Sang Heon
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Choe, Kibaek
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Hong, Seon Pyo
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Jeong, Seung-hwa ...
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Mäkinen, Taija
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Kim, Kwang Soon
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show more...
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Alitalo, Kari
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Surh, Charles D.
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Koh, Gou Young
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Song, Joo-Hye
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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EMBO Reports
- By the university
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Uppsala University