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Effects of blood pr...
Effects of blood pressure and lipid lowering on cognition Results from the HOPE-3 study
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- Bosch, Jackie (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada;McMaster Univ, Sch Rehabil Sci, Hamilton Hlth Sci, Hamilton, ON, Canada
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- O'Donnell, Martin (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada;NUI Galway, Dept Med, Res Board Clin Res Facil, Galway, Ireland
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- Swaminathan, Balakumar (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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- Lonn, Eva Marie (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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- Sharma, Mikul (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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- Dagenais, Gilles (author)
- Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada
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- Diaz, Rafael (author)
- Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina
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- Khunti, Kamlesh (author)
- Univ Leicester, Diabet Res Ctr, Leicester, Leics, England
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- Lewis, Basil S. (author)
- Technion Israel Inst Technol, Ruth & Bruce Rappaport Sch Med, Lady Davis Carmel Med Ctr, Haifa, Israel
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- Avezum, Alvaro (author)
- Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil
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- Held, Claes, 1956- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Keltai, Matyas (author)
- Semmelweis Univ, Budapest, Hungary
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- Reid, Christopher (author)
- Monash Univ, Melbourne, Vic, Australia
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- Toff, William D. (author)
- Univ Leicester, Glenfield Hosp, Leicester Cardiovasc Biomed Res Unit, Dept Cardiovasc Sci, Leicester, Leics, England;Univ Leicester, Glenfield Hosp, Leicester Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, Leicester, Leics, England
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- Dans, Antonio (author)
- Univ Philippines, Coll Med, Manila, Philippines
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- Leiter, Lawrence A. (author)
- Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada
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- Sliwa, Karen (author)
- Univ Cape Town, Soweto Cardiovasc Res Grp, Dept Med, Hatter Inst Cardiovasc Res Africa, Rondebosch, South Africa
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- Lee, Shun Fu (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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- Pogue, Janice M. (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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- Hart, Robert (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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- Yusuf, Salim (author)
- McMaster Univ, Sch Rehabil Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2019
- 2019
- English.
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In: Neurology. - : LIPPINCOTT WILLIAMS & WILKINS. - 0028-3878 .- 1526-632X. ; 92:13, s. E1435-E1446
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: To assess whether long-term treatment with candesartan/hydrochlorothiazide, rosuvastatin, or their combination can slow cognitive decline in older people at intermediate cardiovascular risk.Methods: The Heart Outcomes Prevention Evaluation-3 (HOPE-3) study was a double-blind, randomized, placebo-controlled clinical trial using a 2 x 2 factorial design. Participants without known cardiovascular disease or need for treatment were randomized to candesartan (16 mg) plus hydrochlorothiazide (12.5 mg) or placebo and to rosuvastatin (10 mg) or placebo. Participants who were >= 70 years of age completed the Digit Symbol Substitution Test (DSST), the modified Montreal Cognitive Assessment, and the Trail Making Test Part B at baseline and study end.Results: Cognitive assessments were completed by 2,361 participants from 228 centers in 21 countries. Compared with placebo, candesartan/hydrochlorothiazide reduced systolic blood pressure by 6.0 mm Hg, and rosuvastatin reduced low-density lipoprotein cholesterol by 24.8 mg/dL. Participants were followed up for 5.7 years (median), and 1,626 completed both baseline and study-end assessments. Mean participant age was 74 years (SD +/- 3.5 years); 59% were women; 45% had hypertension; and 24% had >= 12 years of education. The mean difference in change in DSST scores was -0.91 (95% confidence interval [CI] -2.25 to 0.42) for candesartan/hydrochlorothiazide compared with placebo, -0.54 (95% CI -1.88 to 0.80) for rosuvastatin compared with placebo, and -1.43 (95% CI -3.37 to 0.50) for combination therapy vs double placebo. No significant differences were found for other measures.Conclusions: Long-term blood pressure lowering with candesartan plus hydrochlorothiazide, rosuvastatin, or their combination did not significantly affect cognitive decline in older people. ClinicalTrials.gov identifier: NCT00468923. Classification of evidence: This study provides Class II evidence that for older people, candesartan plus hydrochlorothiazide, rosuvastatin, or their combination does not significantly affect cognitive decline.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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Bosch, Jackie
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O'Donnell, Marti ...
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Swaminathan, Bal ...
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Lonn, Eva Marie
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Sharma, Mikul
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Dagenais, Gilles
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Diaz, Rafael
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Khunti, Kamlesh
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Lewis, Basil S.
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Avezum, Alvaro
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Held, Claes, 195 ...
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Keltai, Matyas
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Reid, Christophe ...
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Toff, William D.
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Dans, Antonio
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Leiter, Lawrence ...
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Sliwa, Karen
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Lee, Shun Fu
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Pogue, Janice M.
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Hart, Robert
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Yusuf, Salim
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cardiac and Card ...
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Neurology
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Uppsala University