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No evidence of a causal association of type 2 diabetes and glucose metabolism with atrial fibrillation
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- Harati, Hadi (author)
- Stanford Univ, Sch Med, Dept Med, Div Endocrinol, Stanford, CA USA
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- Zanetti, Daniela (author)
- Stanford Univ, Falk Cardiovasc Res Ctr, Div Cardiovasc Med, Dept Med,Sch Med, 300 Pasteur Dr,CV 273, Stanford, CA 94305 USA
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- Rao, Abhiram (author)
- Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
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- (creator_code:org_t)
- 2019-02-27
- 2019
- English.
- In: Diabetologia. - : SPRINGER. - 0012-186X .- 1432-0428. ; 62:5, s. 800-804
- Journal article (peer-reviewed)
Abstract
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- Aims/hypothesisSeveral epidemiological studies have shown an increased risk of atrial fibrillation in individuals with type 2 diabetes or milder forms of dysglycaemia. We aimed to assess whether this relation is causal using a Mendelian randomisation approach.MethodsTwo-sample Mendelian randomisation was used to obtain estimates of the influence of type 2 diabetes, fasting blood glucose (FBG), and HbA(1c) on the risk of atrial fibrillation. Instrumental variables were constructed using available summary statistics from meta-analyses of genome-wide association studies (GWAS) for type 2 diabetes and associated phenotypes. Pleiotropic SNPs were excluded from the analyses. The most recent GWAS meta-analysis summary statistics for atrial fibrillation, which included over 1 million individuals (approximately 60,000 individuals with atrial fibrillation) was used for outcome analysis.ResultsNeither type 2 diabetes (OR 1.01 [95% CI 0.98, 1.03]; p=0.37), nor FBG (OR 0.95 [95% CI 0.82, 1.09] per mmol/l; p=0.49) or HbA(1c) (OR 1.01 [95% CI, 0.85, 1.17] per mmol/mol [%]; p=0.88) were associated with atrial fibrillation in Mendelian randomisation analyses. We had >80% statistical power to detect ORs of 1.08, 1.06 and 1.09 or larger for type 2 diabetes, FBG and HbA(1c), respectively, for associations with atrial fibrillation.Conclusions/interpretationThis Mendelian randomisation analysis does not support a causal role of clinical significance between genetically programmed type 2 diabetes, FBG or HbA(1c) and development of atrial fibrillation. These data suggest that drug treatment to reduce dysglycaemia is unlikely to be an effective strategy for atrial fibrillation prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Atrial fibrillation
- Genome-wide association
- Mendelian randomisation
- Type 2 diabetes
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- Diabetologia
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- Uppsala University
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