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The anti-inflammato...
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Miao, LingchaoUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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ELSEVIER SCI LTD,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-382803
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382803URI
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https://doi.org/10.1016/j.foodchem.2019.04.005DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Portulaca oleracea L. (Purslane) has great potential as food and traditional drugs in several countries. The purpose of this study was to evaluate the anti-inflammatory effects of purslane extract on lipopolysaccharide (LPS)stimulated RAW 264.7 cells. Purslane extracts significantly reduced LPS-induced synthesis of NO in a dose-dependent manner, as well as the expression levels of iNOS and COX-2. The productions of TNF-alpha and IL-6 were also significantly reduced at the higher dose of 400 mu g/ml. Meanwhile, the expression levels of P65, p-P65, p-MEK and p-I kappa B-alpha were inhibited dose-dependently. The nuclear translocation of P65 was partially prevented by the extract, which explained the inhibition of NF-kappa B pathway. In addition, three reported flavonoids, named luteolin, kaempferol and quercitrin, were identified in the extract, which might be responsible for its anti-inflammatory effects. Above all, our research has partially proved that purslane could be considered as a natural anti-inflammatory agent in further applications.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tao, HongxunUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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Peng, YuUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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Wang, ShengpengUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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Zhong, ZhangfengUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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El-Seedi, HeshamUppsala universitet,Farmakognosi(Swepub:uu)heels173
(författare)
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Dragan, SimonaUniv Med & Farm Timisoara, 2 Eftimie Murgu Sq, Timisoara 300041, Romania
(författare)
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Zengin, GokhanSelcuk Univ, Sci Fac, Dept Biol, Konya, Turkey
(författare)
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Cheang, Wai SanUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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Wang, YitaoUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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Xiao, JianboUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R China
(författare)
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Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Control Chinese Med, Taipa, Macao, Peoples R ChinaFarmakognosi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Food Chemistry: ELSEVIER SCI LTD290, s. 239-2450308-81461873-7072
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Till lärosätets databas
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Miao, Lingchao
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Tao, Hongxun
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Peng, Yu
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Wang, Shengpeng
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Zhong, Zhangfeng
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El-Seedi, Hesham
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visa fler...
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Dragan, Simona
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Zengin, Gokhan
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Cheang, Wai San
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Wang, Yitao
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Xiao, Jianbo
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visa färre...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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Food Chemistry
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Uppsala universitet