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  • Dang, Thanh ChungUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan (author)

Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFR alpha in Adult Brain

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • CELL PRESS,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-382826
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382826URI
  • https://doi.org/10.1016/j.celrep.2019.03.084DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:140738476URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Oligodendrocyte progenitor cells (OPCs) are widely distributed cells of ramified morphology in adult brain that express PDGFR alpha and NG2. They retain mitotic activities in adulthood and contribute to oligodendrogenesis and myelin turnover; however, the regulatory mechanisms of their cell dynamics in adult brain largely remain unknown. Here, we found that global Pdgfra inactivation in adult mice rapidly led to elimination of OPCs due to synchronous maturation toward oligodendrocytes. Surprisingly, OPC densities were robustly reconstituted by the active expansion of Nestin(+) immature cells activated in meninges and brain parenchyma, as well as a few OPCs that escaped from Pdgfra inactivation. The multipotent immature cells were induced in the meninges of Pdgfra-inactivated mice, but not of control mice. Our findings revealed powerful homeostatic control of adult OPCs, engaging dual cellular sources of adult OPC formation. These properties of the adult oligodendrocyte lineage and the alternative OPC source may be exploited in regenerative medicine.

Subject headings and genre

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  • Ishii, YokoUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan;Univ Nagano, Fac Hlth & Human Dev, Dept Hlth Sci, Nagano 3808525, Japan (author)
  • Nguyen, Van De (author)
  • Yamamoto, SeijiUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan (author)
  • Hamashima, TakeruUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan (author)
  • Okuno, NorikoUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan (author)
  • Nguyen, Quang Linh (author)
  • Sang, YangUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan (author)
  • Ohkawa, NoriakiUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Biochem, Toyama 9300194, Japan;JST, CREST, Toyama 9300194, Japan (author)
  • Saitoh, YoshitoUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Biochem, Toyama 9300194, Japan;JST, CREST, Toyama 9300194, Japan (author)
  • Shehata, MohammadUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Biochem, Toyama 9300194, Japan;JST, CREST, Toyama 9300194, Japan (author)
  • Takakura, NobuyukiOsaka Univ, Res Inst Microbial Dis, Dept Signal Transduct, Suita, Osaka 5650871, Japan (author)
  • Fujimori, ToshihikoNatl Inst Basic Biol, Div Embryol, Okazaki, Aichi 4448787, Japan (author)
  • Inokuchi, KaoruUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Biochem, Toyama 9300194, Japan;JST, CREST, Toyama 9300194, Japan (author)
  • Mori, HisashiUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Mol Neurosci, Toyama 9300194, Japan (author)
  • Andrae, JohannaUppsala universitet,Vaskulärbiologi(Swepub:uu)johaandr (author)
  • Betsholtz, ChristerKarolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardio Metab Ctr, S-14157 Huddinge, Sweden(Swepub:uu)chbet517 (author)
  • Sasahara, MasakiyoUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan (author)
  • , an De Nguyen (author)
  • Univ Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, JapanUniv Toyama, Grad Sch Med & Pharmaceut Sci, Dept Pathol, Toyama 9300194, Japan;Univ Nagano, Fac Hlth & Human Dev, Dept Hlth Sci, Nagano 3808525, Japan (creator_code:org_t)

Related titles

  • In:Cell Reports: CELL PRESS27:4, s. 1073-10892211-1247

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