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Mind the gaps :
Mind the gaps : Clinical trial concepts to address unanswered questions in aeroallergen immunotherapy-An NIAID/AHRQ Workshop
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- Wheatley, Lisa M. (author)
- NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD USA
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- Wood, Robert (author)
- Johns Hopkins Univ, Baltimore, MD USA
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- Nadeau, Kari (author)
- Stanford Univ, Stanford, CA 94305 USA
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- Liu, Andrew (author)
- Childrens Hosp Colorado, Aurora, CO USA;Univ Colorado, Sch Med, Aurora, CO USA
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- Zoratti, Edward (author)
- Henry Ford Hosp, Detroit, MI 48202 USA
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- Bacharier, Leonard (author)
- Washington Univ, Sch Med, St Louis, MO 63130 USA
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- Brittain, Erica (author)
- NIAID, Biostat Res Branch, NIH, Rockville, MD USA
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- Calderon, Moises (author)
- Imperial Coll London, London, England
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- Casale, Thomas (author)
- Univ S Florida, Tampa, FL USA
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- Chipps, Bradley (author)
- Capital Allergy & Resp Dis Ctr, Sacramento, CA USA
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- Cox, Linda (author)
- Nova Southeastern Univ, Ft Lauderdale, FL 33314 USA
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- Creticos, Peter S. (author)
- Johns Hopkins Univ, Sch Med, Baltimore, MD USA
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- Desai, Manisha (author)
- Stanford Univ, Quantitat Sci Unit, Stanford, CA 94305 USA
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- Dreborg, Sten, 1933- (author)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Durham, Stephen (author)
- Imperial Coll London, London, England
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- Gergen, Peter J. (author)
- NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD USA
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- Gruchalla, Rebecca (author)
- Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA
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- Nelson, Harold (author)
- Natl Jewish Hlth, Denver, CO USA
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- O'Hehir, Robyn E. (author)
- Alfred Hosp, Melbourne, Vic, Australia;Monash Univ, Sch Med, Melbourne, Vic, Australia
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- Plaut, Marshall (author)
- NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD USA
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- Schwaninger, Julie M. (author)
- NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD USA
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- Tilles, Stephen (author)
- Univ Washington, Seattle, WA 98195 USA
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- Vickery, Brian (author)
- Univ N Carolina, North Carolina Childrens Hosp, Chapel Hill, NC 27515 USA
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- Wittenberg, Kim M. (author)
- Agcy Healthcare Res & Qual, Ctr Evidence & Practice Improvement, Rockville, MD USA
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- Togias, Alkis (author)
- NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD USA
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(creator_code:org_t)
- MOSBY-ELSEVIER, 2019
- 2019
- English.
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In: Journal of Allergy and Clinical Immunology. - : MOSBY-ELSEVIER. - 0091-6749 .- 1097-6825. ; 143:5, s. 1711-1726
- Related links:
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http://www.jacionlin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The Agency for Healthcare Research and Quality and the National Institute of Allergy and Infectious Diseases organized a workshop to develop trial concepts that could improve the use and effectiveness of aeroallergen immunotherapy (AAIT). Expert groups were formed to accomplish the following tasks: (1) propose a study design to compare the effectiveness and safety of subcutaneous versus sublingual AAIT; (2) propose a study design to compare the effectiveness and safety of AAIT by using 1 or a few allergens versus all or most allergens to which a patient is sensitized; (3) propose a study design to determine whether AAIT can alter the progression of childhood allergic airways disease; and (4) propose a study design to determine the optimal dose and duration of AAIT to achieve maximal effectiveness with acceptable safety. Study designs were presented by the workgroups, extensively discussed at the workshop, and revised for this report. The proposed trials would be of long duration and require large highly characterized patient populations. Scientific caveats and feasibility matters are discussed. These concepts are intended to help the development of clinical trials that can address some of the major questions related to the practice of AAIT for the management and prevention of allergic airways disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Aeroallergen
- immunotherapy
- asthma
- allergic rhinitis
- rhinoconjunctivitis
- multi-allergen
- prevention
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wheatley, Lisa M ...
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Wood, Robert
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Nadeau, Kari
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Liu, Andrew
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Zoratti, Edward
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Bacharier, Leona ...
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show more...
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Brittain, Erica
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Calderon, Moises
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Casale, Thomas
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Chipps, Bradley
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Cox, Linda
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Creticos, Peter ...
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Desai, Manisha
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Dreborg, Sten, 1 ...
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Durham, Stephen
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Gergen, Peter J.
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Gruchalla, Rebec ...
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Nelson, Harold
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O'Hehir, Robyn E ...
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Plaut, Marshall
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Schwaninger, Jul ...
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Tilles, Stephen
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Vickery, Brian
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Wittenberg, Kim ...
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Togias, Alkis
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Aller ...
- By the university
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Uppsala University