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Mucispirillum schae...
Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis
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- Herp, Simone (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany
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- Brugiroux, Sandrine (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;Univ Clermont Auvergne, Microbes Intestine Inflammat & Host Susceptibil, INRA 2018, UMR 1071 Inserm,USC, Clermont Ferrand, France
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- Garzetti, Debora (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;German Ctr Infect Res DZIF, Partner Site LMU Munich, D-80336 Munich, Germany
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- Ring, Diana (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;German Ctr Infect Res DZIF, Partner Site LMU Munich, D-80336 Munich, Germany
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- Jochum, Lara M. (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany
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- Beutler, Markus (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany
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- Eberl, Claudia (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany
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- Hussain, Saib (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany
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- Walter, Steffi (author)
- Robert Koch Inst, Project Grp 5, D-38855 Wernigerode, Germany
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- Gerlach, Roman G. (author)
- Robert Koch Inst, Project Grp 5, D-38855 Wernigerode, Germany
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- Ruscheweyh, Hans J. (author)
- Univ Tubingen, Ctr Bioinformat, Tubingen, Germany;Swiss Fed Inst Technol, Inst Microbiol, Dept Biol, Zurich, Switzerland
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- Huson, Daniel (author)
- Univ Tubingen, Ctr Bioinformat, Tubingen, Germany
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- Sellin, Mikael E. (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
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- Slack, Emma (author)
- Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Inst Food Nutr & Hlth, Zurich, Switzerland
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- Hanson, Buck (author)
- Univ Vienna, Dept Microbiol & Ecosyst Sci, Res Network Chem Meets Microbiol, Althanstr 14, A-1090 Vienna, Austria
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- Loy, Alexander (author)
- Univ Vienna, Dept Microbiol & Ecosyst Sci, Res Network Chem Meets Microbiol, Althanstr 14, A-1090 Vienna, Austria
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- Baines, John F. (author)
- Max Planck Inst Evolutionary Biol, August Thienemann Str 2, D-24306 Plon, Germany
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- Bausch, Philipp (author)
- Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Univ Pk 13, DK-2100 Copenhagen, Denmark
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- Basic, Marijana (author)
- Hannover Med Sch, Inst Lab Anim Sci, D-30625 Hannover, Germany;Hannover Med Sch, Cent Anim Facil, D-30625 Hannover, Germany
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- Bleich, Andre (author)
- Hannover Med Sch, Inst Lab Anim Sci, D-30625 Hannover, Germany;Hannover Med Sch, Cent Anim Facil, D-30625 Hannover, Germany
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- Berry, David (author)
- Univ Vienna, Dept Microbiol & Ecosyst Sci, Res Network Chem Meets Microbiol, Althanstr 14, A-1090 Vienna, Austria
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- Stecher, Baerbel (author)
- Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Pettenkoferstr 9a, D-80336 Munich, Germany;German Ctr Infect Res DZIF, Partner Site LMU Munich, D-80336 Munich, Germany
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Cell Host and Microbe. - : Elsevier BV. - 1931-3128 .- 1934-6069. ; 25:5, s. 681-694.e8
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The microbiota and the gastrointestinal mucus layer play a pivotal role in protection against non-typhoidal Salmonella enterica serovar Typhimurium (S. Tm) colitis. Here, we analyzed the course of Salmonella colitis in mice lacking a functional mucus layer in the gut. Unexpectedly, in contrast to mucus-proficient littermates, genetically deficient mice were protected against Salmonellainduced gut inflammation in the streptomycin colitis model. This correlated with microbiota alterations and enrichment of the bacterial phylum Deferribacteres. Using gnotobiotic mice associated with defined bacterial consortia, we causally linked Mucispirillum schaedleri, currently the sole known representative of Deferribacteres present in the mammalian microbiota, to host protection against S. Tm colitis. Inhibition by M. schaedleri involves interference with S. Tm invasion gene expression, partly by competing for anaerobic electron acceptors. In conclusion, this study establishes M. schaedleri, a core member of the murine gut microbiota, as a key antagonist of S. Tm virulence in the gut.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Herp, Simone
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Brugiroux, Sandr ...
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Garzetti, Debora
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Ring, Diana
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Jochum, Lara M.
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Beutler, Markus
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show more...
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Eberl, Claudia
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Hussain, Saib
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Walter, Steffi
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Gerlach, Roman G ...
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Ruscheweyh, Hans ...
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Huson, Daniel
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Sellin, Mikael E ...
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Slack, Emma
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Hanson, Buck
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Loy, Alexander
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Baines, John F.
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Bausch, Philipp
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Basic, Marijana
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Bleich, Andre
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Berry, David
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Stecher, Baerbel
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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Cell Host and Mi ...
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Uppsala University