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OLM alpha 2 Cells B...
OLM alpha 2 Cells Bidirectionally Modulate Learning
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- Siwani, Samer (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Franca, Arthur S. C. (author)
- Uppsala universitet,Genetisk utvecklingsbiologi,Univ Fed Rio Grande do Norte, Brain Inst, BR-59056450 Natal, RN, Brazil;Donders Inst Brain Behav & Cognit, NL-6525 EN Nijmegen, Gelderland, Netherlands
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- Mikulovic, Sanja, 1986- (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Reis, Amilcar (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Hilscher, Markus M (author)
- Uppsala universitet,Genetisk utvecklingsbiologi,Univ Fed Rio Grande do Norte, Brain Inst, BR-59056450 Natal, RN, Brazil
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- Edwards, Steven J. (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Leão, Richardson N (author)
- Uppsala universitet,Genetisk utvecklingsbiologi,Univ Fed Rio Grande do Norte, Brain Inst, BR-59056450 Natal, RN, Brazil
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- Tort, Adriano B. L. (author)
- Univ Fed Rio Grande do Norte, Brain Inst, BR-59056450 Natal, RN, Brazil
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- Kullander, Klas, 1966- (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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(creator_code:org_t)
- CELL PRESS, 2018
- 2018
- English.
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In: Neuron. - : CELL PRESS. - 0896-6273 .- 1097-4199. ; 99:2, s. 404-412
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor alpha 2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLM alpha 2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLM alpha 2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLM alpha 2 cell activation inhibits fear-related memories and that OLM alpha 2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLM alpha 2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neuron
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- By the author/editor
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Siwani, Samer
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Franca, Arthur S ...
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Mikulovic, Sanja ...
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Reis, Amilcar
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Hilscher, Markus ...
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Edwards, Steven ...
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show more...
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Leão, Richardson ...
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Tort, Adriano B. ...
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Kullander, Klas, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuron
- By the university
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Uppsala University