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Data-driven adult a...
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Boudier, AnneUniv Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France
(author)
Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-01-15
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John Wiley & Sons,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-389830
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-389830URI
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https://doi.org/10.1111/all.13697DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BackgroundResearch based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long-term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20years earlier. MethodsThe study relied on two cohorts of adults with asthma with 20-year follow-up, ECRHS (European Community Respiratory Health Survey) and EGEA (Epidemiological study on Genetics and Environment of Asthma). Regression models were used to compare asthma characteristics (current asthma, asthma exacerbations, asthma control, quality of life, and FEV1) at follow-up and the course of FEV(1)between sevencluster-based asthma phenotypes identified20years earlier. ResultsThe analysis included 1325 adults with ever asthma. For each asthma characteristic assessed at follow-up, the risk for adverse outcomes differed significantly between the seven asthma clusters identified at baseline. As compared with the mildest asthma phenotype, ORs (95% CI) for asthma exacerbations varied from 0.9 (0.4 to 2.0) to 4.0 (2.0 to 7.8) and the regression estimates (95% CI) for FEV1% predicted varied from 0.6 (-3.5 to 4.6) to -9.9 (-14.2 to -5.5) between clusters. Change in FEV1 over time did not differ significantly across clusters. ConclusionOur findings show that the long-term risk for poor asthma outcomes differed between comprehensive adult asthma phenotypes identified 20years earlier, and suggest a strong tracking of asthma activity and impaired lung function over time.
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Chanoine, SebastienUniv Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France;Univ Grenoble Alpes, Fac Pharm, Grenoble, France;CHU Grenoble Alpes, Pole Pharm, Grenoble, France
(author)
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Accordini, SimoneUniv Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italy
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Anto, Josep M.Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
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Basagana, XavierCtr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
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Bousquet, JeanINSERM, Aging & Chron Dis U1168, Epidemiol & Publ Hlth Approaches, Villejuif, France
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Demoly, PascalCHU Montpellier, Dept Pneumol, Montpellier, France
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Garcia-Aymerich, JudithCtr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
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Gormand, FredericCHU Lyon, Dept Pneumol, Lyon, France
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Heinrich, JoachimLudwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Comprehens Pneumol Ctr Munich, Univ Hosp,German Ctr Lung Res, Munich, Germany
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
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Kunzli, NinoUniv Basel, Swiss Trop & Publ Hlth Inst, Basel, Switzerland
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Matran, RegisUniv Lille, CHU, Lille, France
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Pison, ChristopheUniv Grenoble Alpes, CHU Grenoble, Clin Univ Pneumol, Pole Thorax & Vaisseaux,INSERM,U1055, Grenoble, France
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Raherison, ChantalUniv Bordeaux, Bordeaux Populat Hlth Res Ctr, Team EPICENE, INSERM,UMR 1219, Bordeaux, France
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Sunyer, JordiCtr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;UPF, Barcelona, Spain;CIBERESP, Barcelona, Spain
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Varraso, RaphaelleINSERM, Aging & Chron Dis U1168, Epidemiol & Publ Hlth Approaches, Villejuif, France
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Jarvis, DeborahImperial Coll, Natl Heart & Lung Inst, London, England
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Leynaert, BenedicteUniv Paris Diderot, Team Epidemiol, INSERM, Unit 1152, Paris, France
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Pin, IsabelleUniv Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France;CHU Grenoble, Dept Pediat, Grenoble, France
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Siroux, ValerieUniv Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France
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Univ Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, FranceUniv Grenoble Alpes, Team Environm Epidemiol Appl Reprod & Resp Hlth, CNRS, IAB,INSERM, Grenoble, France;Univ Grenoble Alpes, Fac Pharm, Grenoble, France;CHU Grenoble Alpes, Pole Pharm, Grenoble, France
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In:Allergy. European Journal of Allergy and Clinical Immunology: John Wiley & Sons74:5, s. 953-9630105-45381398-9995
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Boudier, Anne
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Chanoine, Sebast ...
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Accordini, Simon ...
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Anto, Josep M.
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Basagana, Xavier
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Bousquet, Jean
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Demoly, Pascal
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Garcia-Aymerich, ...
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Janson, Christer
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Kunzli, Nino
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Matran, Regis
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Pison, Christoph ...
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Raherison, Chant ...
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Sunyer, Jordi
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Varraso, Raphael ...
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Jarvis, Deborah
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Leynaert, Benedi ...
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Pin, Isabelle
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Siroux, Valerie
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