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Detection of Breast...
Detection of Breast Tumour Tissue Regions in Histopathological Images using Convolutional Neural Networks
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- Sun, Yibao (author)
- QMUL, EECS, London, England
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- Xu, Zhaoyang (author)
- QMUL, EECS, London, England
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- Strell, Carina (author)
- Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Moro, Carlos Fernandez (author)
- Karolinska Univ Hosp, Dept Clin Pathol Cytol, Stockholm, Sweden
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- Wärnberg, Fredrik (author)
- Uppsala universitet,Endokrinkirurgi
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- Dong, Le (author)
- Univ Elect Sci & Technol China, Sch Comp Sci & Engn, Chengdu, Sichuan, Peoples R China
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- Zhang, Qianni (author)
- QMUL, EECS, London, England
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(creator_code:org_t)
- IEEE, 2018
- 2018
- English.
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In: 2018 IEEE International Conference on Image Processing, Applications and Systems (IPAS). - : IEEE. - 9781728102474 ; , s. 98-103
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ductal carcinoma in situ (DCIS) is considered a pre-invasive breast cancer and sometimes it can develop into an invasive ductal carcinoma. The analysis of histopathological images to detect tumour border of DCIS could provide important information for better diagnosis of patients. We present a deep learning based system to automatically identify DCIS in histopathological images. Specifically, a convolutional neural network (CNN) is first trained to predict labels of small patches cropped out of a histopathological whole slide image. Next, a sliding window method is used to produce a probability map of DCIS. Finally, given the probability map, a tumor border of DCIS is produced and delineated with the method of Marching Cubes to facilitate pathologists' review and assessment. Evaluation of cross validation demonstrates that the CNN model of GoogleNet performs well in histology image patch classification with an overall accuracy of (98.46 +/- 0.40)% and identifies the DCIS tissue patches with a Fl-score of (97.40 +/- 1.18)% (mean +/- variance). Moreover, around 95.6% tumour tissue within the enclosed tumour regions can be identified by our developed method. Finally, the goal of tumor border detection can be well achieved with a few post-processing steps.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Histopathological Images Analysis
- Convolutional Neural Network
- Tumour Border Detection
- Ductal Carcinoma in Situ (DCIS)
Publication and Content Type
- ref (subject category)
- kon (subject category)
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