Search: onr:"swepub:oai:DiVA.org:uu-390413" >
Mechanisms and clin...
Mechanisms and clinical relevance of bacterial heteroresistance
-
- Andersson, Dan I (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Nicoloff, Hervé (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
- Hjort, Karin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
(creator_code:org_t)
- 2019-06-24
- 2019
- English.
-
In: Nature Reviews Microbiology. - : Nature Publishing Group. - 1740-1526 .- 1740-1534. ; 17:8, s. 479-496
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Antibiotic heteroresistance is a phenotype in which a bacterial isolate contains subpopulations of cells that show a substantial reduction in antibiotic susceptibility compared with the main population. Recent work indicates that heteroresistance is very common for several different bacterial species and antibiotic classes. The resistance phenotype is often unstable, and in the absence of antibiotic pressure it rapidly reverts to susceptibility. A common mechanistic explanation for the instability is the occurrence of genetically unstable tandem amplifications of genes that cause resistance. Due to their instability, low frequency and transient character, it is challenging to detect and study these subpopulations, which often leads to difficulties in unambiguously classifying bacteria as susceptible or resistant. Finally, in vitro experiments, mathematical modelling, animal infection models and clinical studies show that the resistant subpopulations can be enriched during antibiotic exposure, and increasing evidence suggests that heteroresistance can lead to treatment failure.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- for (subject category)
Find in a library
To the university's database