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Survival in adult a...
Survival in adult acute lymphoblastic leukaemia (ALL) : A report from the Swedish ALL Registry
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- Lennmyr, Emma (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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- Karlsson, Karin (author)
- Skane Univ Hosp, Dept Haematol Oncol & Radiophys, Lund, Sweden
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- Ahlberg, Lucia (author)
- Univ Hosp Linkoping, Dept Haematol, Linkoping, Sweden,Region Östergötland, Hematologiska kliniken US
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- Garelius, Hege (author)
- Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Dept Med, Gothenburg, Sweden
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- Hulegardh, Erik (author)
- Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Dept Med, Gothenburg, Sweden
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- Izarra, Antonio S. (author)
- Univ Hosp Umea, Ctr Canc, Dept Haematol, Umea, Sweden
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- Joelsson, Joel (author)
- Karolinska Inst, Karolinska Univ Hosp, Dept Med, Div Haematol, Stockholm, Sweden
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- Kozlowski, Piotr (author)
- Orebro Univ, Sch Med Sci, Dept Med, Orebro, Sweden
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- Moicean, Andreea (author)
- Cent Hosp Skovde, Dept Med, Skovde, Sweden
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- Tomaszewska-Toporska, Beata (author)
- Skane Univ Hosp, Dept Haematol Oncol & Radiophys, Lund, Sweden
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- Lubking, Anna (author)
- Skane Univ Hosp, Dept Haematol Oncol & Radiophys, Lund, Sweden
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- Hallböök, Helene (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2019-06-06
- 2019
- English.
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In: European Journal of Haematology. - : WILEY. - 0902-4441 .- 1600-0609. ; 103:2, s. 88-98
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Abstract
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- Objectives: As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care.Methods: We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 and 2015.Results: The median age was 53 years. The frequency of Philadelphia (Ph)-positive leukaemia was 34% of examined B-ALL with a peak incidence at 50-59 years. Five-year overall survival (OS) improved between 1997-2006 and 2007-2015; in patients 18-45 years from 50% (95% CI 43-57) to 65% (95% CI 58-72), 46-65 years from 25% (95% CI 18-32) to 46% (95% CI 37-55) and >65 years from 7% (95% CI 2.6-11) to 11% (95% CI 5.9-16) (P < 0.05). Men with Ph-neg B-ALL 46-65 years had inferior OS compared with women (P < 0.01). Standardised mortality ratio was 5.7 (95% CI 5.0-6.3) for patients who survived 5 years from diagnosis. In multivariable analysis, Ph-positive disease was not associated with impaired prognosis but with lower risk of death in 2007-2015.Conclusions: In a population-based cohort, OS has improved in adult ALL, especially for Ph-positive disease but for middle-aged men with Ph-negative B-ALL outcome was poor. Cure without late toxicity or relapse is still desired.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- acute lymphoblastic leukaemia
- adult
- Philadelphia-positive
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lennmyr, Emma
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Karlsson, Karin
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Ahlberg, Lucia
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Garelius, Hege
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Hulegardh, Erik
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Izarra, Antonio ...
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show more...
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Joelsson, Joel
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Kozlowski, Piotr
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Moicean, Andreea
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Tomaszewska-Topo ...
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Lubking, Anna
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Hallböök, Helene
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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European Journal ...
- By the university
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Uppsala University
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Linköping University
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Karolinska Institutet