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  • Hu, XuchenUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • ELIFE SCIENCES PUBLICATIONS LTD,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-390688
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390688URI
  • https://doi.org/10.7554/eLife.47178DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141219256URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRLs to proceed. In peripheral tissues, the intravascular processing of TRLs by the GPIHBP1-LPL complex is crucial for the generation of lipid nutrients for adjacent parenchymal cells. GPIHBP1 is absent from the capillaries of the brain, which uses glucose for fuel; however, GPIHBP1 is expressed in the capillaries of mouse and human gliomas. Importantly, the GPIHBP1 in glioma capillaries captures locally produced LPL. We use NanoSIMS imaging to show that TRLs marginate along glioma capillaries and that there is uptake of TRL-derived lipid nutrients by surrounding glioma cells. Thus, GPIHBP1 expression in gliomas facilitates TRL processing and provides a source of lipid nutrients for glioma cells.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Matsumoto, KenVIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium (author)
  • Jung, Rachel S.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Weston, Thomas A.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Heizer, Patrick J.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • He, CuiwenUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Sandoval, Norma P.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Allan, Christopher M.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Tu, YipingUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Vinters, Harry V.Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA (author)
  • Liau, Linda M.Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, JCCC, Los Angeles, CA 90095 USA (author)
  • Ellison, Rochelle M.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Morales, Jazmin E.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Baufeld, Lynn J.Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA (author)
  • Bayley, Nicholas A.Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA (author)
  • He, LiqunUppsala universitet,Vaskulärbiologi(Swepub:uu)liqhe592 (author)
  • Betsholtz, ChristerKarolinska Institutet,Uppsala universitet,Vaskulärbiologi,Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Huddinge, Sweden(Swepub:uu)chbet517 (author)
  • Beigneux, Anne P., IUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Nathanson, David A.Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA (author)
  • Gerhardt, HolgerVIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium;Max Delbruck Ctr Mol Med, Berlin, Germany (author)
  • Young, Stephen G.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA (author)
  • Fong, Loren G.Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA (author)
  • Jian, HaiboUniv Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA;Univ Western Australia, Sch Mol Sci, Perth, WA, Australia (author)
  • Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USAVIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium (creator_code:org_t)

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