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FältnamnIndikatorerMetadata
00018809naa a2201741 4500
001oai:DiVA.org:uu-391014
003SwePub
008190821s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:141340901
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3910142 URI
024a https://doi.org/10.1186/s12936-019-2837-42 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1413409012 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Dahal, Prabinu World Wide Antimalarial Resistance Network WWARN, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, WorldWide Antimalarial Resistance Network WWARN, Oxford, England4 aut
2451 0a Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria :b a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
264 c 2019-07-05
264 1b BMC,c 2019
338 a electronic2 rdacarrier
520 a Background: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which constitute competing risk events since they can potentially preclude/pre-empt the detection of subsequent recrudescence of persistent, sub-microscopic primary infections.Methods: Antimalarial studies typically report the risk of recrudescence derived using the Kaplan-Meier (K-M) method, which considers new infections acquired during the follow-up period as censored. Cumulative Incidence Function (CIF) provides an alternative approach for handling new infections, which accounts for them as a competing risk event. The complement of the estimate derived using the K-M method (1 minus K-M), and the CIF were used to derive the risk of recrudescence at the end of the follow-up period using data from studies collated in the WorldWide Antimalarial Resistance Network data repository. Absolute differences in the failure estimates derived using these two methods were quantified. In comparative studies, the equality of two K-M curves was assessed using the log-rank test, and the equality of CIFs using Gray's k-sample test (both at 5% level of significance). Two different regression modelling strategies for recrudescence were considered: cause-specific Cox model and Fine and Gray's sub-distributional hazard model.Results: Data were available from 92 studies (233 treatment arms, 31,379 patients) conducted between 1996 and 2014. At the end of follow-up, the median absolute overestimation in the estimated risk of cumulative recrudescence by using 1 minus K-M approach was 0.04% (interquartile range (IQR): 0.00-0.27%, Range: 0.00-3.60%). The overestimation was correlated positively with the proportion of patients with recrudescence [Pearson's correlation coefficient (rho): 0.38, 95% Confidence Interval (CI) 0.30-0.46] or new infection [rho: 0.43; 95% CI 0.35-0.54]. In three study arms, the point estimates of failure were greater than 10% (the WHO threshold for withdrawing antimalarials) when the K-M method was used, but remained below 10% when using the CIF approach, but the 95% confidence interval included this threshold.Conclusions: The 1 minus K-M method resulted in a marginal overestimation of recrudescence that became increasingly pronounced as antimalarial efficacy declined, particularly when the observed proportion of new infection was high. The CIF approach provides an alternative approach for derivation of failure estimates in antimalarial trials, particularly in high transmission settings.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653 a Plasmodium falciparum
653 a Treatment efficacy study
653 a Competing risk event
700a Simpson, Julie Anneu Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostatist, Melbourne, Vic, Australia4 aut
700a Abdulla, Salimu Ifakara Hlth Inst, Dar Es Salaam, Tanzania4 aut
700a Achan, Janeu MRC Unit, Banjul, Gambia4 aut
700a Adam, Ishagu Univ Khartoum, Fac Med, Khartoum, Sudan4 aut
700a Agarwal, Aartiu Karolinska Institutet4 aut
700a Allan, Richardu Mentor Initiat, Fajara, Gambia4 aut
700a Anvikar, Anupkumar R.u Natl Inst Malaria Res, Sector 8, Dwarka, New Delhi 110077, India4 aut
700a Arinaitwe, Emmanuelu Infect Dis Res Collaborat, Kampala, Uganda4 aut
700a Ashley, Elizabeth A.u Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Myanmar Oxford Clin Res Unit, Yangon, Myanmar4 aut
700a Awab, Ghulam Rahimu Mahidol Univ, Fac Trop Med, Bangkok, Thailand;Minist Publ Hlth, Islam Republ Afghanistan, Kabul, Afghanistan4 aut
700a Bassat, Quiqueu Ctr Investigacao Saude Manhica CISM, Maputo, Mozambique;Univ Barcelona, Hosp Clin, ISGlobal, Barcelona, Spain;ICREA, Pg Lluis Companys 23, Barcelona 08010, Spain4 aut
700a Bjorkman, Andersu Karolinska Inst, Depatment Microbiol Tumour & Cell Biol, Stockholm, Sweden4 aut
700a Bompart, Francoisu Sanofi Access Med, Gentilly, France4 aut
700a Borrmann, Steffenu Kenya Med Res Inst Kilifi, Kilifi, Kenya;Wellcome Trust Res Programme, Kilifi, Kenya;Heidelberg Univ, Sch Med, Dept Infect Dis, Heidelberg, Germany4 aut
700a Bousema, Teunu Radboud Inst Hlth Sci, Radboudumc Nijmegen, Nijmegen, Netherlands;Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands4 aut
700a Broek, Ingridu Centrum Infectieziektebestrijding, Epidemioloog Epidemiol Surveillance RIVM, Bilthoven, Netherlands4 aut
700a Bukirwa, Hasifau African Field Epidemiol Network, Kampala, Uganda4 aut
700a Carrara, Verena I.u Shoklo Malaria Res Unit, Mae Sot, Bangkok, Thailand;Mahidol Oxford Univ Res Unit, Bangkok, Thailand4 aut
700a Corsi, Marcou Private Consultancy Drug Dev Trop Dis, Sigma Tau SpA Ind Farmaceutiche Riunite, Pomezia, Rome, Italy4 aut
700a Cot, Michelu Univ Paris 05, Sorbonne Paris Cite, MERIT, IRD, F-75006 Paris, France4 aut
700a D'Alessandro, Umbertou MRC Unit, Fajara, Gambia;London Sch Hyg & Trop Med, London, England4 aut
700a Davis, Timothy M. E.u Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia4 aut
700a de Wit, Maritu Med Sans Frontieres Operat Ctr Amsterdam, Geneva, Switzerland4 aut
700a Deloron, Philippeu Univ Paris 05, Sorbonne Paris Cite, MERIT, IRD, F-75006 Paris, France4 aut
700a Desai, Meghnau Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA4 aut
700a Dimbu, Pedro Rafaelu Natl Malaria Control Program, Luanda, Angola4 aut
700a Djalle, Djibrineu Inst Pasteur, BP 923, Bangui, Cent Afr Republ4 aut
700a Djimde, Abdoulayeu Univ Sci Techn & Technol Bamako, Fac Pharm, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Bamako, Mali4 aut
700a Dorsey, Grantu Univ Calif San Francisco, Dept Med, San Francisco, CA USA4 aut
700a Doumbo, Ogobara K.u Univ Sci Techn & Technol Bamako, Malaria Res & Training Ctr, Dept Epidemiol Parasit Dis, Fac Med & Odonto Stomatol, Bamako, Mali4 aut
700a Drakeley, Chris J.u London Sch Hyg & Trop Med, Dept Infect & Immun, London, England4 aut
700a Duparc, Stephanu Med Malaria Venture, Geneva, Switzerland4 aut
700a Edstein, Michael D.u Australian Army Malaria Inst, Brisbane, Qld, Australia4 aut
700a Espie, Emmanuelleu R&D Ctr, GSK Vaccines, Clin & Epidemiol Dept, Epicentre, Ave Fleming 20,1300 Wavre,8 Rue St Sabin, F-75011 Paris, France4 aut
700a Faiz, Abulu Malaria Res Grp, Chittagong, Bangladesh;Dev Care Fdn, Dhaka, Bangladesh4 aut
700a Falade, Catherineu Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria4 aut
700a Fanello, Caterinau Univ Oxford, Nuffield Dept Med, Ctr Global Hlth, Oxford, England4 aut
700a Faucher, Jean-Francoisu Besancon Univ Med Ctr, Dept Infect Dis, Mother & Child Hlth Trop Res Unit, Inst Rech Dev IRD, Besancon, France4 aut
700a Faye, Babacaru Univ Cheikh Anta Diop, Fac Med, Dept Med Parasitol, Dakar, Senegal4 aut
700a Fortes, Filomeno de Jesusu Natl Malaria Control Program, Luanda, Angola4 aut
700a Gadalla, Nahla B.u Sudanese Amer Med Assoc, Fairfax, VA USA4 aut
700a Gaye, Oumaru Univ Cheikh Anta Diop, Dept Med Parasitol, Fac Med, Dakar, Senegal4 aut
700a Gil, J. Pedrou Karolinska Institutet4 aut
700a Greenwood, Brianu London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England4 aut
700a Grivoyannis, Anastasiau Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA4 aut
700a Hamed, Kamalu Basilea Pharmaceut Int Ltd, Basel, Switzerland;Novartis Pharmaceut, E Hanover, NJ USA4 aut
700a Hien, Tran Tinhu Oxford Univ Clin Res Unit OUCRU, Ctr Trop Med, Wellcome Trust Major Overseas Program MOP, Oxford, England4 aut
700a Hughes, Davidu Novartis Int AG, Basel, Switzerland4 aut
700a Humphreys, Georginau Wellcome Trust Res Labs, London, England;World Wide Antimalarial Resistance Network WWARN, London, England4 aut
700a Hwang, Jimeeu US Centers Dis Control & Prevent, Div Parasit Dis & Malaria, US Presidents Malaria Initiat Malaria Branch, Atlanta, GA USA;Univ Calif San Francisco, San Francisco, CA 94143 USA;Global Hlth Grp, San Francisco, CA 94143 USA4 aut
700a Ibrahim, Maman Laminouu Ctr Rech Med & Saniataire CERMES, Niamey, Niger4 aut
700a Janssens, Bartu Medecins Sans Frontieres, Phnom Penh, Belgium4 aut
700a Jullien, Vincentu Univ Paris 05, Assistance Publique Hop Paris, Serv Pharmacol Clin, Paris, France;Grp Hosp Cochin Saint Vincent Paul, Inserm U663, WWARN, Paris, France4 aut
700a Juma, Elizabethu Kenya Govt Med Res Ctr, Nairobi, Kenya4 aut
700a Kamugisha, Erasmusu Weill Bugando Univ Coll Hlth Sci, Mwanza, Tanzania4 aut
700a Karema, Corineu Minist Hlth, Natl Malaria Control Program TRAC Plus, Kigali, Rwanda4 aut
700a Karunajeewa, Harin A.u Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia4 aut
700a Kiechel, Jean R.u Drugs Neglected Dis initiat, Geneva, Switzerland4 aut
700a Kironde, Fredu Islam Univ Uganda, Habib Med Sch, Kampala, Uganda4 aut
700a Kofoed, Poul-Eriku Bandim Hlth Project, Indepth Network, Apartado 861, Bissau, Guinea Bissau;Lillebaelt Hosp, Hlth Serv Res Unit, Vejle, Denmark;IRS Univ Southern Denmark, Vejle, Denmark;Kolding Cty Hosp, Dept Paediat, Kolding, Denmark4 aut
700a Kremsner, Peter G.u Univ Tubingen, Inst Trop Med, Tubingen, Germany;Ctr Recherches Medic Lambarene, Lambarene, Gabon4 aut
700a Lameyre, Valerieu Sanofi Access Med, Gentilly, France4 aut
700a Lee, Sue J.u Mahidol Univ, Fac Trop Med, Bangkok, Thailand;Churchill Hosp, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England4 aut
700a Marsh, Kevinu Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Wellcome Trust Res Programme, Kilifi, Kenya;Kenya Govt Med Res Ctr, Kilifi, Kenya4 aut
700a Mårtensson, Andreas,d 1963-u Uppsala universitet,Internationell barnhälsa och nutrition4 aut0 (Swepub:uu)andma331
700a Mayxay, Mayfongu Mahosot Hosp, Lao Oxford Mahosot Hospital, Wellcome Trust Res Unit, Microbiol Lab, Viangchan, Laos4 aut
700a Menan, Herveu Univ Cocody, Dept Parasitol, Fac Pharm, Abidjan, Cote Ivoire;Univ Hlth Sci, Minist Hlth, Fac Postgraduate Studies, Viangchan, Laos4 aut
700a Mens, Petrau Acad Med Ctr, Med Microbiol Parasitol, Amsterdam, Netherlands4 aut
700a Mutabingwa, Theonest K.u Hubert Kairuki Mem Univ, Dar Es Salaam, Tanzania;London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London, England4 aut
700a Ndiaye, Jean-Louisu Univ Cheikh Anta Diop, Fac Med, Parasitol & Mycol Lab, Dakar, Senegal4 aut
700a Ngasala, Billy E.u Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania;Karolinska Inst, Dept Med Solna, Infect Dis Unit, Malaria Res, Stockholm, Sweden4 aut
700a Noedl, Haraldu Med Univ Vienna, Vienna, Austria4 aut
700a Nosten, Francoisu Univ Oxford, Nuffield Dept Med Res Bldg, Ctr Trop Med & Global Hlth, Old Rd Campus, Oxford, England;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Shoklo Malaria Res Unit, Mae Sot, Thailand4 aut
700a Offianan, Andre Toureu Inst Pasteur Cote Ivoire, Malariol Dept, Abidjan, Cote Ivoire4 aut
700a Oguike, Maryu London Sch Hyg & Trop Med, Dept Immunol & Infect, London, England4 aut
700a Ogutu, Bernhards R.u Kenya Govt Med Res Ctr, Kisumu, Kenya;US Army Med Res Unit, Kisumu, Kenya4 aut
700a Olliaro, Pierou UNICEF, UNDP, World Bank, WHO TDR, Geneva, Switzerland4 aut
700a Ouedraogo, Jean Boscou Inst Rech Sci Sante, Direct Regionale Ouest, Bobo Dioulasso, Burkina Faso;Ctr Muraz Bobo Dioulasso, Non Transmissible Dis Dept, Bobo Dioulasso, Burkina Faso4 aut
700a Piola, Patriceu Inst Pasteur Cambodge, Phnom Penh, Cambodia4 aut
700a Plowe, Christopher V.u Duke Univ, Duke Global Hlth Inst, Durham, NC USA4 aut
700a Plucinski, Mateusz M.u US Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, US Presidents Malaria Initiat, Atlanta, GA USA;Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA4 aut
700a Pratt, Oliver Jamesu Minist Hlth & Social Welf, Natl Malaria Control Program, Monrovia, Liberia4 aut
700a Premji, Zulfikaraliu Muhimbili Univ Coll Hlth Sci, Dar Es Salaam, Tanzania4 aut
700a Ramharter, Michaelu Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Bernhard Nocht Inst Trop Med, Dept Trop Med, Hamburg, Germany4 aut
700a Rogier, Christopheu Div Expertise & Def Hlth strategy, Cent Directorate, French Mil Hlth Serv, Paris, France;IRBA, Bretigny Sur Orge, France;URMITE, UMR 6236, Marseille, France4 aut
700a Rombo, Larsu Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)larra728
700a Rosenthal, Philip J.u Univ Calif San Francisco, Dept Med, San Francisco, CA USA4 aut
700a Sawa, Patricku Human Hlth Div, Int Ctr Insect Physiol & Ecol, Mbita, Kenya4 aut
700a Schramm, Birgitu Epicentre, Paris, France4 aut
700a Sibley, Carolu WWARN, Oxford, England;Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA4 aut
700a Sinou, Veroniqueu Aix Marseille Univ, INSERM, SSA, IRBA,MCT, Marseille, France4 aut
700a Sirima, Sodiomonu GRAS, 06 BP 10248, Ouagadougou 06, Burkina Faso4 aut
700a Smithuis, Franku Myanmar Oxford Clin Res Unit, Oxford, England4 aut
700a Staedke, Sarah G.u Infect Dis Res Collaborat, Kampala, Uganda;London Sch Hyg & Trop Med, Dept Clin Res, London, England4 aut
700a Sutanto, Ingeu Univ Indonesia, Dept Parasitol, Fac Med, 6 Salemba Raya, Jakarta 10430, Indonesia4 aut
700a Talisuna, Ambrose Otauu WHO, Reg Off Afr, Brazzaville, Rep Congo;Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England4 aut
700a Tarning, Joelu WorldWide Antimalarial Resistance Network, Oxford, England;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand4 aut
700a Taylor, Walter R. J.u Mahidol Univ, Fac Trop Med, Bangkok, Thailand4 aut
700a Temu, Emmanuelu MENTOR Initiat, Crawley, England4 aut
700a Thriemer, Kamala L.u Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia4 aut
700a Thuy, Nhien Nguyenu Oxford Univ Clin Res Unit OUCRU, Wellcome Trust Major Overseas Program MOP, Ctr Trop Med, Oxford, England4 aut
700a Udhayakumar, Venkatachalamu Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Malaria Branch & Presidents Malaria Initiat, Atlanta, GA USA4 aut
700a Ursing, Johanu Karolinska Institutet4 aut
700a van Herp, Michelu Operat Ctr Brussels, Med Sans Frontieres, Brussels, Belgium;Univ Amsterdam, Acad Med Ctr, Div Infect Dis, Ctr Trop Med & Travel Med, Amsterdam, Netherlands4 aut
700a van Vugt, Michele4 aut
700a Whitty, Christopheru London Sch Hyg & Trop Med, Dept Infect & Trop Dis, Malaria Partnership, London, England4 aut
700a William, Yavou Univ Cocody, Dept Parasitol, Fac Pharm, Abidjan, Cote Ivoire4 aut
700a Winnips, Cornelisu NovartisInternat AG, Basel, Switzerland4 aut
700a Zongo, Issakau Inst Rech Sci Sante, Direct Regionale lOuest, Bobo Dioulasso, Burkina Faso4 aut
700a Guerin, Philippeu World Wide Antimalarial Resistance Network WWARN, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England4 aut
700a Price, Ric N.u World Wide Antimalarial Resistance Network WWARN, Oxford, England;Menzies Sch Hlth Res Charles Darwin Univ, Darwin, NT, Australia;Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford, England4 aut
700a Stepniewska, Kasiau World Wide Antimalarial Resistance Network WWARN, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, WorldWide Antimalarial Resistance Network WWARN, Oxford, England4 aut
710a World Wide Antimalarial Resistance Network WWARN, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, WorldWide Antimalarial Resistance Network WWARN, Oxford, Englandb Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostatist, Melbourne, Vic, Australia4 org
773t Malaria Journald : BMCg 18q 18x 1475-2875
856u https://doi.org/10.1186/s12936-019-2837-4y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1344476/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://malariajournal.biomedcentral.com/track/pdf/10.1186/s12936-019-2837-4
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-391014
8564 8u https://doi.org/10.1186/s12936-019-2837-4
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141340901

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