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Combinations of Spo...
Combinations of Spok genes create multiple meiotic drivers in Podospora
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- Vogan, Aaron A. (author)
- Uppsala universitet,Systematisk biologi
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- Ament-Velásquez, Sandra Lorena, 1988- (author)
- Uppsala universitet,Systematisk biologi
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- Granger-Farbos, Alexandra (author)
- Univ Bordeaux, Bordeaux, France
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- Svedberg, Jesper (author)
- Uppsala universitet,Systematisk biologi
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- Bastiaans, Eric (author)
- Wageningen Univ, Wageningen, Netherlands
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- Debets, Alfons J. M. (author)
- Wageningen Univ, Wageningen, Netherlands
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- Coustou, Virginie (author)
- Univ Bordeaux, Bordeaux, France
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- Yvanne, Helene (author)
- Univ Bordeaux, Bordeaux, France
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- Clave, Corinne (author)
- Univ Bordeaux, Bordeaux, France
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- Saupe, Sven J. (author)
- Univ Bordeaux, Bordeaux, France
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- Johannesson, Hanna (author)
- Uppsala universitet,Systematisk biologi,Uppsala Univ, Organismal Biol, Uppsala, Sweden
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(creator_code:org_t)
- ELIFE SCIENCES PUBLICATIONS LTD, 2019
- 2019
- English.
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In: eLIFE. - : ELIFE SCIENCES PUBLICATIONS LTD. - 2050-084X. ; 8
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https://doi.org/10.7...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.7...
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Abstract
Subject headings
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- Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the Spok gene family underlies the Psks. The combination of Spok genes at different chromosomal locations defines the spore killer types and creates a killing hierarchy within a population. We identify two novel Spok homologs located within a large (74-167 kbp) region (the Spok block) that resides in different chromosomal locations in different strains. We confirm that the SPOK protein performs both killing and resistance functions and show that these activities are dependent on distinct domains, a predicted nuclease and kinase domain. Genomic and phylogenetic analyses across ascomycetes suggest that the Spok genes disperse through cross-species transfer, and evolve by duplication and diversification within lineages.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vogan, Aaron A.
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Ament-Velásquez, ...
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Granger-Farbos, ...
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Svedberg, Jesper
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Bastiaans, Eric
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Debets, Alfons J ...
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Coustou, Virgini ...
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Yvanne, Helene
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Clave, Corinne
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Saupe, Sven J.
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Johannesson, Han ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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eLIFE
- By the university
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Uppsala University