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  • Hjort, MarcusUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi (author)

Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-08-01
  • AMER ASSOC CLINICAL CHEMISTRY,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-392574
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392574URI
  • https://doi.org/10.1373/clinchem.2018.301085DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141455786URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD).METHODS: Ninety-one biomarkers were measured with a proximity extension assay 3 months after MI in 97 MINOCA patients, 97 age-and sex-matched MI-CAD patients, and 98 controls. Lasso analyses (penalized logistic regression models) and adjusted multiple linear regression models were used for statistical analyses.RESULTS: In the Lasso analysis (MINOCA vs MI-CAD), 8 biomarkers provided discriminatory value: P-selectin glycoprotein ligand 1, C-X-C motif chemokine 1, TNF-related activation-induced cytokine, and pappalysin-1 (PAPPA) with increasing probabilities of MINOCA, and tissue-type plasminogen activator, B-type natriuretic peptide, myeloperoxidase, and interleukin-1 receptor antagonist protein with increasing probabilities of MI-CAD. Comparing MINOCA vs controls, 7 biomarkers provided discriminatory value: N-terminal pro-B-type natriuretic peptide, renin, NF-kappa-B essential modulator, PAPPA, interleukin-6, and soluble urokinase plasminogen activator surface receptor with increasing probabilities of MINOCA, and agouti-related protein with increasing probabilities of controls. Adjusted multiple linear regression analyses showed that group affiliation was associated with the concentrations of 7 of the 8 biomarkers in the comparison MINOCA vs MI-CAD and 5 of the 7 biomarkers in MINOCA vs controls.CONCLUSIONS: Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts. 

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  • Eggers, Kai M.,1962-Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)kaieg561 (author)
  • Lindhagen, LarsKarolinska Institutet,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)lla11670 (author)
  • Agewall, StefanKarolinska Institutet,Univ Oslo, Inst Clin Sci, Oslo Univ Hosp, Oslo, Norway (author)
  • Brolin, Elin B.Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci Intervent & Technol, Stockholm, Sweden (author)
  • Collste, OlovSoder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden (author)
  • Daniel, MariaSoder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden (author)
  • Ekenbäck, ChristinaKarolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden (author)
  • Frick, MatsKarolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden (author)
  • Henareh, LoghmanKarolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden (author)
  • Hofman-Bang, ClaesDanderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden (author)
  • Malmqvist, KarinDanderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden (author)
  • Spaak, JonasKarolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden (author)
  • Sörensson, PederKarolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden (author)
  • Y-Hassan, ShamsKarolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden (author)
  • Tornvall, PerKarolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden (author)
  • Lindahl, Bertil,1957-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227 (author)
  • Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

Related titles

  • In:Clinical Chemistry: AMER ASSOC CLINICAL CHEMISTRY65:8, s. 1023-10300009-91471530-8561

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