Search: onr:"swepub:oai:DiVA.org:uu-392837" >
Tumor-to-blood rati...
Tumor-to-blood ratio for assessment of somatostatin receptor density in neuroendocrine tumors using 68Ga-DOTATOC and 68Ga-DOTATATE.
-
- Ilan, Ezgi (author)
- Uppsala universitet,Radiologi,Institutionen för immunologi, genetik och patologi
-
- Velikyan, Irina, 1966- (author)
- Uppsala universitet,Radiologi
-
- Sandström, Mattias (author)
- Uppsala universitet,Radiologi
-
show more...
-
- Sundin, Anders, 1954- (author)
- Uppsala universitet,Radiologi
-
- Lubberink, Mark (author)
- Uppsala universitet,Radiologi
-
show less...
-
(creator_code:org_t)
- 2019-07-13
- 2020
- English.
-
In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 61:2, s. 217-221
- Related links:
-
http://jnm.snmjourna...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- PET/CT with 68Ga-DOTA-somatostatin analogs has been tested for therapy monitoring in patients with neuroendocrine tumors (NETs). However, standardized uptake values (SUV) in tumors do not correlate with the net influx rate (Ki), as a representation of the somatostatin receptor (SSTR) expression. In this study, tumor-to-blood-ratio (TBR) was evaluated as an alternative tool for semi-quantitative assessment of 68Ga-DOTATOC and 68Ga-DOTATATE tumor uptake and as a therapy monitoring tool for patients with NETs. Methods: Twenty-two NET patients underwent a 45-min dynamic PET/CT scan after injection of 68Ga-DOTATOC and/or 68Ga-DOTATATE. Ki was determined using the Patlak method and TBR was calculated for the 40-45 min time interval. Results: A linear relation was found between Ki and TBR, with a square of Pearson correlation (R2) of 0.98 and 0.93 for 68Ga-DOTATOC and 68Ga-DOTATATE, respectively. Conclusion: High correlation was found between Ki and TBR. Hence, TBR reflects SSTR density more accurately than SUV and is suggested as the preferred metrics for semi-quantitative assessment of 68Ga-DOTATOC and 68Ga-DOTATATE tumor uptake.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- 68Ga-DOTATOC/68Ga-DOTATATE
- Molecular Imaging
- Net influx rate
- Neuroendocrine
- Neuroendocrine tumors
- PET/CT
- SUV
- Tumor-to-blood ratio
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database