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IL-22 Binding Prote...
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
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- Lindahl, Hannes (author)
- Karolinska Institutet
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- Guerreiro-Cacais, Andre O. (author)
- Karolinska Institutet
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- Bedri, Sahl Khalid (author)
- Karolinska Institutet
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- Linnerbauer, Mathias (author)
- Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17177 Stockholm, Sweden
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- Linden, Magdalena (author)
- Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17177 Stockholm, Sweden
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- Abdelmagid, Nada (author)
- Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17177 Stockholm, Sweden
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- Tandre, Karolina (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
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- Hollins, Claire (author)
- MedImmune, Resp Inflammat & Autoimmun Res, Cambridge CB21 6GH, England
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- Irving, Lorraine (author)
- MedImmune, High Content Imaging, Cambridge CB21 6GH, England
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- Glover, Colin (author)
- MedImmune, Resp Inflammat & Autoimmun Res, Cambridge CB21 6GH, England
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- Jones, Clare (author)
- MedImmune, Resp Inflammat & Autoimmun Res, Cambridge CB21 6GH, England
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- Alfredsson, Lars (author)
- Karolinska Institutet
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- Rönnblom, Lars (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Dept Med Sci Rheumatol & Sci Life Labs, S-75105 Uppsala, Sweden
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- Kockum, Ingrid (author)
- Karolinska Institutet
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- Khademi, Mohsen (author)
- Karolinska Institutet
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- Jagodic, Maja (author)
- Karolinska Institutet
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- Olsson, Tomas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-08-15
- 2019
- English.
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In: Journal of Immunology. - : AMER ASSOC IMMUNOLOGISTS. - 0022-1767 .- 1550-6606. ; 203:4, s. 888-898
- Related links:
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https://www.jimmunol...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Subject headings
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- Genome-wide association studies have mapped the specific sequence variants that predispose for multiple sclerosis (MS). The pathogenic mechanisms that underlie these associations could be leveraged to develop safer and more effective MS treatments but are still poorly understood. In this article, we study the genetic risk variant rs17066096 and the candidate gene that encodes IL-22 binding protein (IL-22BP), an antagonist molecule of the cytokine IL-22. We show that monocytes from carriers of the risk genotype of rs17066096 express more IL-22BP in vitro and cerebrospinal fluid levels of IL-22BP correlate with MS lesion load on magnetic resonance imaging. We confirm the pathogenicity of IL-22BP in both rat and mouse models of MS and go on to suggest a pathogenic mechanism involving lack of IL-22-mediated inhibition of T cell-derived IFN-gamma expression. Our results demonstrate a pathogenic role of IL-22BP in three species with a potential mechanism of action involving T cell polarization, suggesting a therapeutic potential of IL-22 in the context of MS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lindahl, Hannes
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Guerreiro-Cacais ...
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Bedri, Sahl Khal ...
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Linnerbauer, Mat ...
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Linden, Magdalen ...
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Abdelmagid, Nada
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show more...
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Tandre, Karolina
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Hollins, Claire
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Irving, Lorraine
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Glover, Colin
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Jones, Clare
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Alfredsson, Lars
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Rönnblom, Lars
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Kockum, Ingrid
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Khademi, Mohsen
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Jagodic, Maja
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Olsson, Tomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Journal of Immun ...
- By the university
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Uppsala University
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Karolinska Institutet