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Stroma-normalised v...
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
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- Mezheyeuski, Artur (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Hrynchyk, Ina (author)
- City Clin Pathologoanat Bur, Minsk, BELARUS
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- Herrera, Mercedes (author)
- Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Karlberg, Mia (author)
- Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Osterman, Eric (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Ragnhammar, Peter (author)
- Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
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- Edler, David (author)
- Karolinska Univ Hosp, Dept Mol Med & Surg, Stockholm, Sweden
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- Portyanko, Anna (author)
- NN Alexandrov Natl Canc Ctr Belarus, Minsk, BELARUS
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- Pontén, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Sjöblom, Tobias (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Ostman, Arne (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-07-10
- 2019
- English.
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In: British Journal of Cancer. - : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 121:4, s. 303-311
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Abstract
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- BACKGROUND: Identification of biomarkers associated with benefit of adjuvant chemotherapy in stage II/III colon cancer is an important task. METHODS: Vessel density (VD) and tumour stroma were analysed in a randomised-trial-derived discovery cohort (n = 312) and in a stage II/III group of a population-based validation cohort (n = 85). VD was scored separately in the tumour centre, invasive margin and peritumoral stroma compartments and quantitated as VD/total analysed tissue area or VD/stroma area. RESULTS: High stroma-normalised VD in the invasive margin was associated with significantly longer time to recurrence and overall survival (OS) (p = 0.002 and p = 0.006, respectively) in adjuvant-treated patients of the discovery cohort, but not in surgery-only patients. Stroma-normalised VD in the invasive margin and treatment effect were significantly associated according to a formal interaction test (p = 0.009). Similarly, in the validation cohort, high stroma-normalised VD was associated with OS in adjuvant-treated patients, although statistical significance was not reached (p = 0.051). CONCLUSION: Through the use of novel digitally scored vessel-density-related metrics, this exploratory study identifies stroma-normalised VD in the invasive margin as a candidate marker for benefit of adjuvant 5-FU-based chemotherapy in stage II/III colon cancer. The findings, indicating particular importance of vessels in the invasive margin, also suggest biological mechanisms for further exploration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mezheyeuski, Art ...
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Hrynchyk, Ina
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Herrera, Mercede ...
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Karlberg, Mia
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Osterman, Eric
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Ragnhammar, Pete ...
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show more...
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Edler, David
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Portyanko, Anna
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Pontén, Fredrik
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Sjöblom, Tobias
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Glimelius, Bengt
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Ostman, Arne
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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British Journal ...
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Uppsala University
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Karolinska Institutet